New triterpenoid saponins from the leaves of Ilex chinensis

被引：10

作者：

Li, Ruo-Fei

Xia, Wen-Qi

Liu, Jia-Bao

Cui, Bao-Song

Hou, Qi

Sun, Hua

Li, Shuai ^{[1
]}

机构：

[1] Peking Union Med Coll, 1 Xian Nong Tan Rd, Beijing 100050, Peoples R China

来源：

FITOTERAPIA | 2018年 / 131卷

关键词：

Ilex chinensis; Aquifoliaceae; triterpenoid saponins; hepatoprotective activity; NO production inhibitory activity;

D O I：

10.1016/j.fitote.2018.10.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight new triterpenoid saponins, including four ursane-type saponins, ilexchinenosides J-M (1-4), and four oleanane-type saponins, ilexchinenosides N-Q (5-8), along with three known triterpenoid saponins (9-11) were isolated from the leaves of Ilex chinensis Sims. Their structures were established by 1D, 2D NMR and MS spectroscopic analyses and through comparisons with known compounds. Moreover, compounds 1, 3, 5, 7-9 and 11 exhibited significant levels of hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in in vitro assays while compound 10 had moderately inhibitory effects on the NO production of lipopolysaccharide (LPS)-induced murine macrophages.

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收藏

页码：134 / 140

页数：7

相关论文

共 22 条

[11]

Mei Z., 1996, CHINA J CHIN MAT MED, V21, P480

[12] THE STRUCTURE OF ROTUNGENOSIDE, A NEW BITTER TRITERPENE GLUCOSIDE FROM ILEX-ROTUNDA [J].

NAKATANI, M ;

HATANAKA, S ;

KOMURA, H ;

KUBOTA, T ;

HASE, T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1989, 62 (02) :469-473

[13] Complete assignments of 1H and 13C NMR resonances of oleanolic acid, 18α-oleanolic acid, ursolic acid and their 11-oxo derivatives [J].

Seebacher, W ;

Simic, N ;

Weis, R ;

Saf, R ;

Kunert, O .

MAGNETIC RESONANCE IN CHEMISTRY, 2003, 41 (08) :636-638

[14] Facile discrimination of aldose enantiomers by reversed-phase HPLC [J].

Tanaka, Takashi ;

Nakashima, Tatsuya ;

Ueda, Toshihisa ;

Tomii, Kenji ;

Kouno, Isao .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (06) :899-901

[15] Saponins from Strasburgetia robusta [J].

Um, BH ;

Pouplin, T ;

Lobstein, A ;

Weniger, B ;

Litaudon, M ;

Anton, R .

FITOTERAPIA, 2001, 72 (05) :591-593

[16] Ilelic Acids A and B, Two Unusual Triterpenes with a Seven-Membered Ring from Ilex latifolia [J].

Wang, Cun-Qin ;

Wang, Lei ;

Fan, Chun-Lin ;

Zhang, Dong-Mei ;

Huang, Xiao-Jun ;

Jiang, Ren-Wang ;

Bai, Liang-Liang ;

Shi, Jun-Min ;

Wang, Ying ;

Ye, Wen-Cai .

ORGANIC LETTERS, 2012, 14 (16) :4102-4105

[17] Six new triterpenoid saponins from the leaves of Ilex oblonga and their inhibitory activities against TMV replication [J].

Wu, Zu-Jian ;

Ouyang, Ming-An ;

Wang, Cong-Zhou ;

Zhang, Zheng-Kun .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (03) :422-427

[18] Triterpenoids from the leaves of Ilex chinensis [J].

Xia, Wen-Qi ;

Li, Ruo-Fei ;

Liu, Jia-Bao ;

Cui, Bao-Song ;

Hou, Qi ;

Sun, Hua ;

Li, Shuai .

PHYTOCHEMISTRY, 2018, 148 :113-121

[19] Antiproliferative Triterpenes from the Leaves and Twigs of Juglans sinensis on HSC-T6 Cells [J].

Yang, Heejung ;

Jeong, Eun Ju ;

Kim, Jinwoong ;

Sung, Sang Hyun ;

Kim, Young Choong .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (04) :751-756

[20] Phenolic and triterpene glycosides from the stems of Ilex litseaefolia [J].

Zhang, AL ;

Ye, Q ;

Li, BG ;

Qi, HY ;

Zhang, GL .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (10) :1531-1535