Three-dimensional retinal imaging with ultrahigh resolution, Fourier spectral domain optical coherence tomography

被引：0

作者：

Srinivasan, V ^{[1
]}

Wojtkowski, M ^{[1
]}

Ko, T ^{[1
]}

Carvalho, M ^{[1
]}

Fujimoto, J ^{[1
]}

Duker, J ^{[1
]}

Schumann, J ^{[1
]}

Kowalczyk, A ^{[1
]}

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

来源：

Ophthalmic Technologies XV | 2005年 / 5688卷

关键词：

Optical Coherence Tomography; mapping; segmentation; StratusOCT; 3D; rendering; ophthalmology;

D O I：

10.1117/12.591367

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Ultrahigh resolution OCT using broadband light sources achieves improved axial image resolutions of similar to 2-3 um compared to standard 10 um resolution OCT used in current commercial instruments. High-speed OCT using Fourier/spectral domain detection enables dramatic increases in imaging speeds. 3D OCT retinal imaging is performed in human subjects using high-speed, uttrahigh resolution OCT, and the concept of an OCT fundus image is introduced. Three-dimensional data and high quality cross-sectional images of retinal pathologies are presented. These results show that 3D OCT may be used to improve coverage of the retina, precision of cross-sectional image registration, quality of cross-sectional images, and visualization of subtle changes in retinal topography. 3D OCT imaging and mapping promise to help elucidate the structural changes associated with retinal disease as well as to improve early diagnosis and monitoring of disease progression and response to treatment.

引用

页码：90 / 99

页数：10

共 28 条

[1] Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography [J].

Cense, B ;

Nassif, NA ;

Chen, T ;

Pierce, M ;

Yun, SH ;

Park, BH ;

Bouma, BE ;

Tearney, GJ ;

de Boer, JF .

OPTICS EXPRESS, 2004, 12 (11) :2435-2447

[2] In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography [J].

Cense, B ;

Chen, HC ;

Park, BH ;

Pierce, MC ;

de Boer, JF .

JOURNAL OF BIOMEDICAL OPTICS, 2004, 9 (01) :121-125

[3] Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].

Choma, MA ;

Sarunic, MV ;

Yang, CH ;

Izatt, JA .

OPTICS EXPRESS, 2003, 11 (18) :2183-2189

[4] Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography [J].

de Boer, JF ;

Cense, B ;

Park, BH ;

Pierce, MC ;

Tearney, GJ ;

Bouma, BE .

OPTICS LETTERS, 2003, 28 (21) :2067-2069

[5] In vivo ultrahigh-resolution optical coherence tomography [J].

Drexler, W ;

Morgner, U ;

Kärtner, FX ;

Pitris, C ;

Boppart, SA ;

Li, XD ;

Ippen, EP ;

Fujimoto, JG .

OPTICS LETTERS, 1999, 24 (17) :1221-1223

[6] Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography [J].

Drexler, W ;

Sattmarin, H ;

Hermann, B ;

Ko, TH ;

Stur, M ;

Unterhuber, A ;

Scholda, C ;

Findl, O ;

Wirtitsch, M ;

Fujimoto, JG ;

Fercher, AF .

ARCHIVES OF OPHTHALMOLOGY, 2003, 121 (05) :695-706

[7] Ultrahigh-resolution ophthalmic optical coherence tomography [J].

Drexler, W ;

Morgner, U ;

Ghanta, RK ;

Kärtner, FX ;

Schuman, JS ;

Fujimoto, JG .

NATURE MEDICINE, 2001, 7 (04) :502-507

[8] MEASUREMENT OF INTRAOCULAR DISTANCES BY BACKSCATTERING SPECTRAL INTERFEROMETRY [J].

FERCHER, AF ;

HITZENBERGER, CK ;

KAMP, G ;

ELZAIAT, SY .

OPTICS COMMUNICATIONS, 1995, 117 (1-2) :43-48

[9]

Häusler G, 1998, J BIOMED OPT, V3, P21, DOI 10.1117/1.429899

[10] Topography of diabetic macular edema with optical coherence tomography [J].

Hee, MR ;

Puliafito, CA ;

Duker, JS ;

Reichel, E ;

Coker, JG ;

Wilkins, JR ;

Schuman, JS ;

Swanson, EA ;

Fujimoto, JG .

OPHTHALMOLOGY, 1998, 105 (02) :360-370

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