A ternary doped single matrix material with dual functions of bone repair and multimodal tracking for applications in orthopedics and dentistry

被引:12
作者
Li, Xiyu [1 ,2 ]
Zou, Qin [3 ]
Chen, Li [3 ]
Li, Wei [1 ,2 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
UP-CONVERSION NANOPARTICLES; HYDROXYAPATITE NANOPARTICLES; COATINGS; EMISSION;
D O I
10.1039/c8tb02041h
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Hydroxyapatite (HA) has been broadly used for the repair of human hard tissues due to its bioactivity and similarity to the mineral of bones and teeth. We prepared a fluorine (F), ytterbium (Yb) and holmium (Ho) ternary doped HA (HYH-F) material and investigated its dual functions of bone repair and multimodal tracking. The results showed that the HYH-F material could display clear X-ray micro-computed tomography (Micro-CT) images based on Yb ions, and Ho ions due to its superparamagnetic properties for magnetic resonance imaging (MRI), while the F ions could enhance the upconversion (UC) fluorescence of the Yb/Ho combination. The ternary doped HYH-F material shows good compatibility with cells and bone tissue. A joint usage of Micro-CT imaging and UC fluorescence imaging distinctly and synergistically demonstrated the distribution state and degradation of the HYH-F material during new bone reconstruction. The single matrix HA material with ternary doping will be beneficial for future biomedical investigation and applications, and it can not only be a bone repair biomaterial, but also provide lifelong multimodal tracking efficacy.
引用
收藏
页码:6047 / 6056
页数:11
相关论文
共 41 条
[11]   On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles [J].
Fan, Wenpei ;
Bu, Wenbo ;
Shi, Jianlin .
ADVANCED MATERIALS, 2016, 28 (21) :3987-4011
[12]   Recent Progress in Rare Earth Micro/Nanocrystals: Soft Chemical Synthesis, Luminescent Properties, and Biomedical Applications [J].
Gai, Shili ;
Li, Chunxia ;
Yang, Piaoping ;
Lin, Jun .
CHEMICAL REVIEWS, 2014, 114 (04) :2343-2389
[13]   The future of biologic coatings for orthopaedic implants [J].
Goodman, Stuart B. ;
Yao, Zhenyu ;
Keeney, Michael ;
Yang, Fan .
BIOMATERIALS, 2013, 34 (13) :3174-3183
[14]  
Hench L., 2013, An Introduction to Bioceramics, VSecond, DOI DOI 10.1142/P884
[15]   Facile preparation of rare-earth based fluorescence/MRI dual-modal nanoprobe for targeted cancer cell imaging [J].
Huang, Sa ;
Chen, Peng ;
Xu, Chen .
TALANTA, 2017, 165 :161-166
[16]   Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications [J].
Idris, Niagara Muhammad ;
Jayakumar, Muthu Kumara Gnanasammandhan ;
Bansal, Akshaya ;
Zhang, Yong .
CHEMICAL SOCIETY REVIEWS, 2015, 44 (06) :1449-1478
[17]   Accelerated Bone Regeneration by Nitrogen-Doped Carbon Dots Functionalized with Hydroxyapatite Nanoparticles [J].
Khajuria, Deepak Kumar ;
Kumar, Vijay Bhooshan ;
Gigi, Dana ;
Gedanken, Aharon ;
Karasik, David .
ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (23) :19373-19385
[18]   Processing of AB-type carbonated hydroxyapatite Ca10-x(PO4)6-x(CO3)x(OH)2-x-2y(CO3)y ceramics with controlled composition [J].
Lafon, J. P. ;
Champion, E. ;
Bernache-Assollant, D. .
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2008, 28 (01) :139-147
[19]   Targeted multimodal imaging modalities [J].
Lee, Seung Yong ;
Jeon, Seong Ik ;
Jung, Seulhee ;
Chung, In Jae ;
Ahn, Cheol-Hee .
ADVANCED DRUG DELIVERY REVIEWS, 2014, 76 :60-78
[20]  
LeGeros RZ, 2008, WOODHEAD PUBL MATER, P367, DOI 10.1533/9781845694227.2.367