Preparation, characterization, molecular docking and in vitro evaluation of two novel morin hydrate/CD inclusion complexes

被引：7

作者：

Ren, Si-Hao ^{[1
]}

Zhang, Jian-Qiang ^{[1
]}

Yan, Hui-Huan ^{[1
]}

Zheng, Xi ^{[2
]}

Zhu, Hong-You ^{[1
]}

Jin, Yi ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China

[2] Yunnan Univ, State Key Lab Conservat & Utilizat Bioresource Yu, Kunming 650091, Peoples R China

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2016年 / 85卷 / 3-4期

基金：

中国国家自然科学基金;

关键词：

Morin hydrate; Characterization; Cyclodextrin; Inclusion complex; Molecular modeling; ANTIINFLAMMATORY ACTIVITY; CYCLODEXTRIN; ANTIOXIDANT; SOLUBILITY; STABILITY; ENZYMES; NMR; AKT;

D O I：

10.1007/s10847-016-0631-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two novel water-soluble morin hydrate (MH) complexes, composed of a hydrophobic MH core and hydrophilic cyclodextrin shell, were prepared and systematically investigated in both aqueous solution and the solid state by means of UV-Vis spectroscopy, H-1 NMR, 2D NMR (ROESY), SEM, FT-IR, DSC, TGA, and XRD analysis. The characterization information resulting from these investigations revealed that the MH/cyclodextrin inclusion complexes formed by the MH with CD in 1:1 stoichiometry, and demonstrated satisfactory water solubility. The MH/cyclodextrin complexes still maintained antibacterial activity in vitro test against Staphylococcus aureus bacteria.

引用

页码：317 / 328

页数：12

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