Preparation, characterization, molecular docking and in vitro evaluation of two novel morin hydrate/CD inclusion complexes

被引：7
|
作者：
Ren, Si-Hao [1 ]
Zhang, Jian-Qiang [1 ]
Yan, Hui-Huan [1 ]
Zheng, Xi [2 ]
Zhu, Hong-You [1 ]
Jin, Yi [1 ]
Lin, Jun [1 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China
[2] Yunnan Univ, State Key Lab Conservat & Utilizat Bioresource Yu, Kunming 650091, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2016年 / 85卷 / 3-4期
基金：
中国国家自然科学基金;
关键词：
Morin hydrate; Characterization; Cyclodextrin; Inclusion complex; Molecular modeling; ANTIINFLAMMATORY ACTIVITY; CYCLODEXTRIN; ANTIOXIDANT; SOLUBILITY; STABILITY; ENZYMES; NMR; AKT;
D O I：
10.1007/s10847-016-0631-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two novel water-soluble morin hydrate (MH) complexes, composed of a hydrophobic MH core and hydrophilic cyclodextrin shell, were prepared and systematically investigated in both aqueous solution and the solid state by means of UV-Vis spectroscopy, H-1 NMR, 2D NMR (ROESY), SEM, FT-IR, DSC, TGA, and XRD analysis. The characterization information resulting from these investigations revealed that the MH/cyclodextrin inclusion complexes formed by the MH with CD in 1:1 stoichiometry, and demonstrated satisfactory water solubility. The MH/cyclodextrin complexes still maintained antibacterial activity in vitro test against Staphylococcus aureus bacteria.
引用
收藏
页码：317 / 328
页数：12
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