The expanded role of fatty acid metabolism in cancer: new aspects and targets

被引：121

作者：

Chen, Ming ^{[1
]}

Huang, Jiaoti ^{[1
]}

机构：

[1] Duke Univ, Sch Med, Duke Canc Inst, Dept Pathol, Durham, NC 27514 USA

来源：

PRECISION CLINICAL MEDICINE | 2019年 / 2卷 / 03期

基金：

美国国家卫生研究院;

关键词：

cancer; fatty acid metabolism; lipid metabolism; metabolic plasticity;

D O I：

10.1093/pcmedi/pbz017

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer cells undergo metabolic reprogramming to support cell proliferation, growth, and dissemination. Alterations in lipid metabolism, and specifically the uptake and synthesis of fatty acids (FAs), comprise one well-documented aspect of this reprogramming. Recent studies have revealed an expanded range of roles played by FA in promoting the aggressiveness of cancer while simultaneously identifying new potential targets for cancer therapy. This article provides a brief review of these advances in our understanding of FA metabolism in cancer, highlighting both recent discoveries and the inherent challenges caused by the metabolic plasticity of cancer cells in targeting lipid metabolism for cancer therapy.

引用

页码：183 / 191

页数：9

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