The history and future challenges associated with the hydrogenation of vinyl fluorides

被引：19

作者：

Sedgwick, Daniel M. ^{[1
,2
,3
]}

Hammond, Gerald B. ^{[1
]}

机构：

[1] Univ Louisville, Dept Chem, Louisville, KY 40292 USA

[2] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain

[3] Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2018年 / 207卷

基金：

美国国家科学基金会;

关键词：

Vinyl fluoride; Fluoroalkene; Catalytic hydrogenation; Palladium; Iridium; Rhodium; CATALYZED ASYMMETRIC HYDROGENATION; CARBOXYLIC-ACIDS; ENANTIOSELECTIVE HYDROGENATION; AMINO-ACIDS; COMPLEXES; OLEFINS; ACCESS; BOND; HYDRODEFLUORINATION; HYDROGENOLYSIS;

D O I：

10.1016/j.jfluchem.2017.12.019

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Catalytic hydrogenation is one of the most powerful transformations available in synthetic chemistry; there have been three Nobel Laureates rewarded for their work in the field. Despite the advances in substrate scope and the development of enantioselective versions of this transformation, vinyl fluorides remain somewhat under-represented. Successful hydrogenation of vinyl fluorides can give rise to a fluorine-containing stereocenter, an important feature which has great potential in many areas of chemistry. This review aims to explore the history of vinyl fluorides as substrates in hydrogenation reactions, and to highlight modern day challenges and unresolved issues regarding this ambitious transformation.

引用

页码：45 / 58

页数：14

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