The role of NADPH oxidases in neuronal development

被引:37
|
作者
Terzi, Aslihan [1 ,2 ]
Suter, Daniel M. [1 ,2 ,3 ]
机构
[1] Purdue Univ, Dept Biol Sci, 915 West State St, W Lafayette, IN 47907 USA
[2] Purdue Univ, Purdue Inst Integrat Neurosci, W Lafayette, IN 47907 USA
[3] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47907 USA
基金
美国国家科学基金会;
关键词
NADPH oxidases; Nox; ROS; Hydrogen peroxide; Neural stem cells; Neuronal development; Neurogenesis; Neurite growth; Growth cone; Cytoskeleton; Actin; Regeneration; EXTRACELLULAR-SUPEROXIDE DISMUTASE; CHRONIC GRANULOMATOUS-DISEASE; GROWTH CONE MOTILITY; CENTRAL-NERVOUS-SYSTEM; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; REDOX REGULATION; NOX-FAMILY; SUBCELLULAR-LOCALIZATION; ACTIN CYTOSKELETON;
D O I
10.1016/j.freeradbiomed.2020.04.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reactive oxygen species (ROS) are critical for maintaining cellular homeostasis and function when produced in physiological ranges. Important sources of cellular ROS include NADPH oxidases (Nox), which are evolutionary conserved multi-subunit transmembrane proteins. Nox-mediated ROS regulate variety of biological processes including hormone synthesis, calcium signaling, cell migration, and immunity. ROS participate in intracellular signaling by introducing post-translational modifications to proteins and thereby altering their functions. The central nervous system (CNS) expresses different Nox isoforms during both development and adulthood. Here, we review the role of Nox-mediated ROS during CNS development. Specifically, we focus on how individual Nox isoforms contribute to signaling in neural stem cell maintenance and neuronal differentiation, as well as neurite outgrowth and guidance. We also discuss how ROS regulates the organization and dynamics of the actin cytoskeleton in the neuronal growth cone. Finally, we review recent evidence that Nox-derived ROS modulate axonal regeneration upon nervous system injury.
引用
收藏
页码:33 / 47
页数:15
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