Concise Review: Limbal Epithelial Stem Cell Therapy: Controversies and Challenges

被引：70
作者：
O'Callaghan, Anna R. [1 ]
Daniels, Julie T. [1 ]
机构：
[1] UCL, Dept Ocular Biol & Therapeut, Inst Ophthalmol, London EC1V 9EL, England
来源：
STEM CELLS | 2011年 / 29卷 / 12期
关键词：
Corneal epithelium; Stem cell niche; Stem cells; Cultured cells; corneal diseases; OCULAR SURFACE RECONSTRUCTION; SINGLE CORNEAL CELLS; AMNIOTIC MEMBRANE; IN-VITRO; EX-VIVO; TRANSPLANTATION; DEFICIENCY; SURVIVAL; SHEETS; NICHE;
D O I：
10.1002/stem.756
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Limbal epithelial stem cells (LESCs) are a population of stem cells responsible for maintenance and repair of the corneal surface. Injury and disease can result in a deficiency of these stem cells, the vision affecting condition called limbal stem cell deficiency (LSCD) in which the cornea becomes opaque, vascularized, and inflamed. Cultured LESC therapy was first described in 1997, and LESCs cultured from either patients or donors have been used to successfully treat LSCD. In this review, some of the challenges and controversies associated with cultured LESC therapy will be discussed including alternative stem cell sources. STEM CELLS 2011;29:1923-1932
引用
收藏
页码：1923 / 1932
页数：10
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