Executive dysfunction and disability in elderly patients with major depression

被引：105

作者：

Kiosses, DN ^{[1
]}

Klimstra, S ^{[1
]}

Murphy, C ^{[1
]}

Alexopoulos, GS ^{[1
]}

机构：

[1] Cornell Univ, Weill Coll Med, Ithaca, NY USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2001年 / 9卷 / 03期

关键词：

D O I：

10.1176/appi.ajgp.9.3.269

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Tbe authors studied 126 elderly patients without dementia and with unipolar major depression. Impairment in instrumental activities of daily living (IADLs) was significantly associated with age (P <0.0001), gender (P <0.001), medical burden (P = 0.013), severity of depression (P = 0.01), initiation/perseveration (IP; P = 0.035), and IP X depression (P = 0.029). Depression was associated with IADL impairment mainly in patients with impaired IP Among the cognitive impairments, IP-only contributed significantly to IADL impairment, whereas attention, construction, conceptualization, and memory did not. Attention to executive function and disability may guide clinical management and lead to development of innovative pharmacological and behavioral interventions.

引用

页码：269 / 274

页数：6

共 41 条

[1] Executive dysfunction and long-term outcomes of geriatric depression [J].