A facile base-promoted domino Michael/O-alkylation reaction for the construction of succinimide-substituted 3(2H)-furanones

被引：0

作者：

Wang, Wu ^{[1
]}

Liang, Guojuan ^{[1
]}

Bai, Yan ^{[1
]}

Bai, Lijuan ^{[1
]}

Zhou, Hui ^{[1
]}

Yu, Yu ^{[1
]}

Zhou, Jing ^{[1
]}

机构：

[1] Chongqing Med Univ, Sch Pharmaceut Sci, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China

来源：

ARKIVOC | 2017年

基金：

中国国家自然科学基金;

关键词：

Succinimide-substituted 3(2H)-furanones; Michael/O-alkylation; domino reaction; maleimides; gamma-halogenated-beta-ketoesters; REACTIONS ASYMMETRIC-SYNTHESIS; TETRONIC ACID-DERIVATIVES; ENANTIOSELECTIVE SYNTHESIS; ALDOL REACTION; MALEIMIDES; CYCLOADDITION;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel base-promoted domino Michael/O-alkylation reaction of maleimides with gamma-halogenated-beta-ketoesters is described. A variety of new succinimide-substituted 3(2H)-furanones were obtained in excellent yields (up to 96%) under simple and mild conditions. The structure of the new compound 3a was determined by single crystal X-ray analysis and a reaction pathway is proposed. [GRAPHICS] .

引用

页码：236 / 248

页数：13

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