What if Gut Hormones Aren't Really Hormones: DPP-4 Inhibition and Local Action of GLP-1 in the Gastrointestinal Tract

被引:19
作者
D'Alessio, David A. [1 ]
机构
[1] Univ Cincinnati, Dept Med, Div Endocrinol Diabet & Metab, Cincinnati, OH 45267 USA
关键词
GLUCAGON-LIKE PEPTIDE-1; GLUCOSE-TOLERANCE; SITAGLIPTIN; SECRETION; IV;
D O I
10.1210/en.2011-1385
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:2925 / 2926
页数:2
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共 13 条
  • [1] Efficacy and safety of incretin therapy in type 2 diabetes - Systematic review and meta-analysis
    Amori, Renee E.
    Lau, Joseph
    Pittas, Anastassios G.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (02): : 194 - 206
  • [2] Biology of incretins: GLP-1 and GIP
    Baggio, Laurie L.
    Drucker, Daniel J.
    [J]. GASTROENTEROLOGY, 2007, 132 (06) : 2131 - 2157
  • [3] The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose
    Bock, Gerlies
    Man, Chiara Dalla
    Micheletto, Francesco
    Basu, Rita
    Giesler, Paula D.
    Laugen, Jeanette
    Deacon, Carolyn F.
    Holst, Jens J.
    Toffolo, Gianna
    Cobelli, Claudio
    Rizza, Robert A.
    Vella, Adrian
    [J]. CLINICAL ENDOCRINOLOGY, 2010, 73 (02) : 189 - 196
  • [4] Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor
    Burcelin, R
    Da Costa, A
    Drucker, D
    Thorens, B
    [J]. DIABETES, 2001, 50 (08) : 1720 - 1728
  • [5] Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system
    D'Alessio, David
    Lu, Wendell
    Sun, William
    Zheng, Shuqin
    Yang, Qing
    Seeley, Randy
    Woods, Stephen C.
    Tso, Patrick
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 293 (06) : R2163 - R2169
  • [6] Genetic Tracing of Nav1.8-Expressing Vagal Afferents in the Mouse
    Gautron, Laurent
    Sakata, Ichiro
    Udit, Swalpa
    Zigman, Jeffrey M.
    Wood, John N.
    Elmquist, Joel K.
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2011, 519 (15) : 3085 - 3101
  • [7] Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    Hansen, L
    Deacon, CF
    Orskov, C
    Holst, JJ
    [J]. ENDOCRINOLOGY, 1999, 140 (11) : 5356 - 5363
  • [8] Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
    Holst, JJ
    Deacon, CF
    [J]. DIABETOLOGIA, 2005, 48 (04) : 612 - 615
  • [9] Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones
    Ionut, V
    Hucking, K
    Liberty, I
    Bergman, R
    [J]. DIABETOLOGIA, 2005, 48 (05) : 967 - 975
  • [10] Incretin-based therapies for type 2 diabetes mellitus
    Lovshin, Julie A.
    Drucker, Daniel J.
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2009, 5 (05) : 262 - 269