Important Role of Oxidative Stress Biomarkers in Huntington's Disease

被引：72

作者：

Tunez, Isaac ^{[1
]}

Sanchez-Lopez, Fernando ^{[2
]}

Agueera, Eduardo ^{[2
]}

Fernandez-Bolanos, Ricardo ^{[3
]}

Manuel Sanchez, Francisco ^{[3
]}

Tasset-Cuevan, Inmaculada ^{[1
]}

机构：

[1] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Fac Med, Dept Bioquim & Biol Mol, Cordoba, Spain

[2] Hosp Univ Reina Sofia Cordoba, IMIBIC, Serv Neurol, Cordoba, Spain

[3] Hosp Univ Nuestra Senora Valme, Serv Neurol, Seville, Spain

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 15期

关键词：

GLUTATHIONE-PEROXIDASE ACTIVITIES; SUPEROXIDE-DISMUTASE; BLOOD; BRAIN;

D O I：

10.1021/jm200605a

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.

引用

页码：5602 / 5606

页数：5

共 50 条

[31] Important role of antioxidants in oxidative stress
Armstrong, Scott A.
Korsmeyer, Stanley J.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2005, 37 (03) : 75 - 75
[32] Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients
Ciancarelli, Irene
De Amicis, Daniela
Di Massimo, Caterina
Di Scanno, Carla
Pistarini, Caterina
D'Orazio, Nicolantonio
Ciancarelli, Maria Giuliana Tozzi
BIOMARKERS, 2014, 19 (06) : 452 - 456
[33] Role of Inflammatory and Oxidative Stress Pathway Biomarkers in Renal Disease in Gout
Alduraibi, Fatima
Ricart, Karina
Patel, Rakesh
Szalai, Alexander
Melnick, Joshua
Singh, Jasvinder
ARTHRITIS & RHEUMATOLOGY, 2020, 72
[34] Oxidative stress in Q175 mouse model of Huntington's disease
Lopez Couselo, Federico
Saba, Julieta
Bruno, Julieta
Carniglia, Lila
Durand, Daniela
Lasaga, Mercedes
Caruso, Carla
JOURNAL OF NEUROCHEMISTRY, 2022, 162 : 147 - 148
[35] Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro
Colle, Dirleise
Hartwig, Juliana M.
Soares, Felix A. Antunes
Farina, Marcelo
BRAIN RESEARCH BULLETIN, 2012, 87 (4-5) : 397 - 405
[36] Cerebrospinal Fluid Biomarkers for Huntington's Disease
Byrne, Lauren M.
Wild, Edward J.
JOURNAL OF HUNTINGTONS DISEASE, 2016, 5 (01) : 1 - 13
[37] Salivary biomarkers for Huntington's disease (HD)
Corey-Bloom, J.
Aikin, A.
Park, S.
Haque, A.
Nathan, A.
Granger, D.
Granger, S.
Thomas, E.
MOVEMENT DISORDERS, 2017, 32
[38] Fluid and imaging biomarkers for Huntington's disease
Zeun, Paul
Scahill, Rachael I.
Tabrizi, Sarah J.
Wild, Edward J.
MOLECULAR AND CELLULAR NEUROSCIENCE, 2019, 97 : 67 - 80
[39] Biomarkers and the oxidative stress theory of disease
Ghezzi, Pietro
FREE RADICAL BIOLOGY AND MEDICINE, 2016, 96 : S7 - S7
[40] Longitudinal Neuroimaging Biomarkers in Huntington's Disease
Rees, Elin M.
Scahill, Rachael I.
Hobbs, Nicola Z.
JOURNAL OF HUNTINGTONS DISEASE, 2013, 2 (01) : 21 - 39

← 1 2 3 4 5 →