The effect of COX-2 inhibitors on periprosthetic osteolysis

被引:20
作者
Im, GI [1 ]
Kwon, BC [1 ]
Lee, KB [1 ]
机构
[1] Hallym Univ Hosp, Dept Orthopaed, Anyang 431070, South Korea
关键词
osteolysis; joint replacement; cyclooxygenase; inflammation; immunohistochemistry;
D O I
10.1016/S0142-9612(03)00523-4
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
We aimed to test the hypothesis that COX(cyclooxygenase)-2 inhibitors suppress periprosthetic osteolysis in a rabbit model. Porous coated titanium bar was inserted into distal femur of 24 skeletally mature New Zealand white rabbits. The rabbits were randomized into 3 groups. Group I (8 rabbits) was the control group. In Group II (8 rabbits), 5 mg of ultrahigh molecular weight polyethylene particles was inserted along with prosthesis. In Group III (8 rabbits), the same procedure as in Group II was done and a COX-2 inhibitor (celecoxib, Pharmacia: 10 mg/day) was administered for 7 weeks. Rabbits were sacrificed after 8 weeks of implantation. Gross, radiological, histological, and immunohistochemical assessments were done. Gross examination showed that one implant in Group II was loose. In radiological evaluation, focal osteolysis was found in 2 rabbits of Group II and I rabbit of Group III. Linear osteolysis was found in 2 rabbits of Group II and I rabbit of Group III. On histological examination, focal area of granulation tissue laden with macrophages was observed in 6 rabbits of Group II and 6 rabbits of Group III. The mean number of osteoclasts as demonstrated by tartarate positive acid phosphatase staining was 0.5 +/- 0.5 in Group I, 6.5 +/- 2.7 in Group II, 3.6 +/- 2.6 in Group III (p < 0.05). Immunohistochemical staining for inducible nitric acid synthase and COX-2 did not show significant difference between Groups II and III. The overall results of this study suggest that COX-2 inhibitors in the therapeutic dose may have a place in suppressing the process of periprosthetic osteolysis. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:269 / 275
页数:7
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