Strain-relatedness of methicillin-resistant Staphylococcus aureus isolates recovered from patients with repeated infection

被引：41

作者：

Huang, Susan S. ^{[1
,2
]}

Diekema, Daniel J. ^{[5
,6
,7
]}

Warren, David K. ^{[8
]}

Zuccotti, Gianna ^{[9
]}

Winokur, Patricia L. ^{[5
]}

Tendolkar, Shailesh ^{[6
]}

Boyken, Linda ^{[6
]}

Datta, Rupak ^{[3
,4
]}

Jones, Rebecca M. ^{[8
]}

Ward, Melissa A. ^{[7
]}

Aubrey, Tanya ^{[9
]}

Onderdonk, Andrew B. ^{[2
]}

Garcia, Christian ^{[3
,4
]}

Platt, Richard ^{[2
,3
,4
]}

机构：

[1] Univ Calif Irvine, Med Ctr, Div Infect Dis, Sch Med, Orange, CA 92868 USA

[2] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[3] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA

[4] Harvard Pilgrim Healthcare, Boston, MA USA

[5] Univ Iowa, Coll Med, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USA

[6] Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USA

[7] Univ Iowa Hosp & Clin, Program Hosp Epidemiol, Iowa City, IA 52242 USA

[8] Washington Univ, Sch Med, Dept Internal Med, Div Infect Dis, St Louis, MO 63110 USA

[9] Mem Sloan Kettering Canc Ctr, Dept Internal Med, Div Infect Dis, New York, NY 10021 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 46卷 / 08期

关键词：

D O I：

10.1086/529381

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Invasive disease following methicillin-resistant Staphylococcus aureus (MRSA) detection is common, regardless of whether initial detection involves colonization or infection. We assessed the genetic relatedness of isolates obtained >= 2 weeks apart representing either repeated infections or colonization-infection sets to determine if infections are likely to be caused by previously harbored strains. We found that MRSA infection following initial colonization or infection is caused by the same strain in most cases, suggesting that a single successful attempt at decolonization may prevent the majority of later infection.

引用

页码：1241 / 1247

页数：7

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