Generation of High Quality Memory B Cells

被引：23

作者：

Inoue, Takeshi ^{[1
]}

Shinnakasu, Ryo ^{[1
]}

Kurosaki, Tomohiro ^{[1
,2
,3
]}

机构：

[1] Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Lymphocyte Differentiat, Osaka, Japan

[2] Osaka Univ, Ctr Infect Dis Educ & Res, Osaka, Japan

[3] RIKEN, Ctr Integrat Med Sci, Lab Lymphocyte Differentiat, Yokohama, Kanagawa, Japan

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 12卷

关键词：

memory B cell; germinal center; vaccine; broadly neutralizing antibody; BCR affinity; GERMINAL-CENTER; TRANSCRIPTION FACTOR; AFFINITY MATURATION; SELECTION; CENTERS; MUTATION; SUBSETS; DIFFERENTIATION; SPECIFICITIES; EXPRESSION;

D O I：

10.3389/fimmu.2021.825813

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protection against pathogen re-infection is mediated, in large part, by two humoral cellular compartments, namely, long-lived plasma cells and memory B cells. Recent data have reinforced the importance of memory B cells, particularly in response to re-infection of different viral subtypes or in response with viral escape mutants. In regard to memory B cell generation, considerable advancements have been made in recent years in elucidating its basic mechanism, which seems to well explain why the memory B cells pool can deal with variant viruses. Despite such progress, efforts to develop vaccines that induce broadly protective memory B cells to fight against rapidly mutating pathogens such as influenza virus and HIV have not yet been successful. Here, we discuss recent advances regarding the key signals and factors regulating germinal center-derived memory B cell development and activation and highlight the challenges for successful vaccine development.

引用

页数：10

共 75 条

[1] Factors in B cell competition and immunodominance [J].

Abbott, Robert K. ;

Crotty, Shane .

IMMUNOLOGICAL REVIEWS, 2020, 296 (01) :120-131

[2] Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens [J].

Abbott, Robert K. ;

Lee, Jeong Hyun ;

Menis, Sergey ;

Skog, Patrick ;

Rossi, Meghan ;

Ota, Takayuki ;

Kulp, Daniel W. ;

Bhullar, Deepika ;

Kalyuzhniy, Oleksandr ;

Havenar-Daughton, Colin ;

Schief, William R. ;

Nemazee, David ;

Crotty, Shane .

IMMUNITY, 2018, 48 (01) :133-+

[3] B cell memory: building two walls of protection against pathogens [J].

Akkaya, Munir ;

Kwak, Kihyuck ;

Pierce, Susan K. .

NATURE REVIEWS IMMUNOLOGY, 2020, 20 (04) :229-238

[4] Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses [J].

Alameh, Mohamad-Gabriel ;

Tombacz, Istvan ;

Bettini, Emily ;

Lederer, Katlyn ;

Sittplangkoon, Chutamath ;

Wilmore, Joel R. ;

Gaudette, Brian T. ;

Soliman, Ousamah Y. ;

Pine, Matthew ;

Hicks, Philip ;

Manzoni, Tomaz B. ;

Knox, James J. ;

Johnson, John L. ;

Laczko, Dorottya ;

Muramatsu, Hiromi ;

Davis, Benjamin ;

Meng, Wenzhao ;

Rosenfeld, Aaron M. ;

Strohmeier, Shirin ;

Lin, Paulo J. C. ;

Mui, Barbara L. ;

Tam, Ying K. ;

Kariko, Katalin ;

Jacquet, Alain ;

Krammer, Florian ;

Bates, Paul ;

Cancro, Michael P. ;

Weissman, Drew ;

Prak, Eline T. Luning ;

Allman, David ;

Locci, Michela ;

Pardi, Norbert .

IMMUNITY, 2021, 54 (12) :2877-+

[5] Immune history profoundly affects broadly protective B cell responses to influenza [J].

Andrews, Sarah F. ;

Huang, Yunping ;

Kaur, Kaval ;

Popova, Lyubov I. ;

Ho, Irvin Y. ;

Pauli, Noel T. ;

Dunand, Carole J. Henry ;

Taylor, William M. ;

Lim, Samuel ;

Huang, Min ;

Qu, Xinyan ;

Lee, Jane-Hwei ;

Salgado-Ferrer, Marlene ;

Krammer, Florian ;

Palese, Peter ;

Wrammert, Jens ;

Ahmed, Rafi ;

Wilson, Patrick C. .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (316)

[6] Defining B cell immunodominance to viruses [J].

Angeletti, Davide ;

Gibbs, James S. ;

Angel, Matthew ;

Kosik, Ivan ;

Hickman, Heather D. ;

Frank, Gregory M. ;

Das, Suman R. ;

Wheatley, Adam K. ;

Prabhakaran, Madhu ;

Leggat, David J. ;

McDermott, Adrian B. ;

Yewdell, Jonathan W. .

NATURE IMMUNOLOGY, 2017, 18 (04) :456-+

[7] Germinal centers: programmed for affinity maturation and antibody diversification [J].

Bannard, Oliver ;

Cyster, Jason G. .

CURRENT OPINION IN IMMUNOLOGY, 2017, 45 :21-30

[8] Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses [J].

Bannard, Oliver ;

McGowan, Simon J. ;

Ersching, Jonatan ;

Ishido, Satoshi ;

Victora, Gabriel D. ;

Shin, Jeoung-Sook ;

Cyster, Jason G. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 213 (06) :993-1009

[9] Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination [J].

Burnett, Deborah L. ;

Langley, David B. ;

Schofield, Peter ;

Hermes, Jana R. ;

Chan, Tyani D. ;

Jackson, Jennifer ;

Bourne, Katherine ;

Reed, Joanne H. ;

Patterson, Kate ;

Porebski, Benjamin T. ;

Brink, Robert ;

Christ, Daniel ;

Goodnow, Christopher C. .

SCIENCE, 2018, 360 (6385) :223-226

[10] Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance [J].

Cirelli, Kimberly M. ;

Carnathan, Diane G. ;

Nogal, Bartek ;

Martin, Jacob T. ;

Rodriguez, Oscar L. ;

Upadhyay, Amit A. ;

Enemuo, Chiamaka A. ;

Gebru, Etse H. ;

Choe, Yury ;

Viviano, Federico ;

Nakao, Catherine ;

Pauthner, Matthias G. ;

Reiss, Samantha ;

Cottrell, Christopher A. ;

Smith, Melissa L. ;

Bastidas, Raiza ;

Gibson, William ;

Wolabaugh, Amber N. ;

Melo, Mariane B. ;

Cossette, Benjamin ;

Kumar, Venkatesh ;

Patel, Nirav B. ;

Tokatlian, Talar ;

Menis, Sergey ;

Kulp, Daniel W. ;

Burton, Dennis R. ;

Murrell, Ben ;

Schief, William R. ;

Bosinger, Steven E. ;

Ward, Andrew B. ;

Watson, Corey T. ;

Silvestri, Guido ;

Irvine, Darrell J. ;

Crotty, Shane .

CELL, 2019, 177 (05) :1153-+

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