Markers of Cardiac Autonomic Function During Consecutive Day Peak Exercise Tests in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

被引:6
作者
Nelson, Maximillian J. [1 ]
Buckley, Jonathan D. [1 ]
Thomson, Rebecca L. [1 ,2 ,3 ]
Bellenger, Clint R. [1 ]
Davison, Kade [1 ]
机构
[1] Univ South Australia, UniSA Allied Hlth & Human Performance, Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia
[2] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia
[3] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia
关键词
Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; autonomic function; heart rate; fatigue; heart rate variability; HEART-RATE-VARIABILITY; ATHLETIC TRAINING STATUS; MAXIMAL RATE; NERVOUS-SYSTEM; BLOOD-PRESSURE; PERFORMANCE; FIBROMYALGIA; RELIABILITY; INCREASE; MUSCLE;
D O I
10.3389/fphys.2021.771899
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have been shown to exhibit altered ventilatory characteristics on the second of two progressive maximal cardiopulmonary exercise tests (CPET) performed on consecutive days. However, maximal exercise can exacerbate symptoms for ME/CFS patients and cause significant post-exertional malaise. Assessment of heart rate (HR) parameters known to track post-exertional fatigue may represent more effective physiological markers of the condition and could potentially negate the need for maximal exercise testing. Sixteen ME/CFS patients and 10 healthy controls underwent a sub-maximal warm-up followed by CPET on two consecutive days. Ventilation, ratings of perceived exertion, work rate (WR) and HR parameters were assessed throughout on both days. During sub-maximal warm-up, a time effect was identified for the ratio of low frequency to high frequency power of HR variability (p=0.02) during sub-maximal warm-up, and for HR at ventilatory threshold (p=0.03), with both being higher on Day Two of testing. A significant group (p<0.01) effect was identified for a lower post-exercise HR recovery (HRR) in ME/CFS patients. Receiver operator characteristic curve analysis of HRR revealed an area under the curve of 74.8% (p=0.02) on Day One of testing, with a HRR of 34.5bpm maximising sensitivity (63%) and specificity (40%) suggesting while HRR values are altered in ME/CFS patients, low sensitivity and specificity limit its potential usefulness as a biomarker of the condition.
引用
收藏
页数:8
相关论文
共 47 条
[1]   The effects of frequency of encouragement on performance during maximal exercise testing [J].
Andreacci, JL ;
LeMura, LM ;
Cohen, SL ;
Urbansky, EA ;
Chelland, SA ;
Von Duvillard, SP .
JOURNAL OF SPORTS SCIENCES, 2002, 20 (04) :345-352
[2]   A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis [J].
Barnden, Leighton R. ;
Crouch, Benjamin ;
Kwiatek, Richard ;
Burnet, Richard ;
Mernone, Anacleto ;
Chryssidis, Steve ;
Scroop, Garry ;
Del Fante, Peter .
NMR IN BIOMEDICINE, 2011, 24 (10) :1302-1312
[3]   The effect of functional overreaching on parameters of autonomic heart rate regulation [J].
Bellenger, Clint R. ;
Thomson, Rebecca L. ;
Robertson, Eileen Y. ;
Davison, Kade ;
Nelson, Maximillian J. ;
Karavirta, Laura ;
Buckley, Jonathan D. .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2017, 117 (03) :541-550
[4]   Monitoring Athletic Training Status Through Autonomic Heart Rate Regulation: A Systematic Review and Meta-Analysis [J].
Bellenger, Clint R. ;
Fuller, Joel T. ;
Thomson, Rebecca L. ;
Davison, Kade ;
Robertson, Eileen Y. ;
Buckley, Jonathan D. .
SPORTS MEDICINE, 2016, 46 (10) :1461-1486
[5]   Monitoring athletic training status using the maximal rate of heart rate increase [J].
Bellenger, Clint R. ;
Thomson, Rebecca L. ;
Howe, Peter R. C. ;
Karavirta, Laura ;
Buckley, Jonathan D. .
JOURNAL OF SCIENCE AND MEDICINE IN SPORT, 2016, 19 (07) :590-595
[6]   Reliability of Heart Rate Measures during Walking before and after Running Maximal Efforts [J].
Boullosa, D. A. ;
Barros, E. S. ;
del Rosso, S. ;
Nakamura, F. Y. ;
Leicht, A. S. .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2014, 35 (12) :999-1005
[7]   Monitoring training status ith HR measures: do all roads lead to Rome? [J].
Buchheit, Martin .
FRONTIERS IN PHYSIOLOGY, 2014, 5
[8]  
Camm AJ, 1996, CIRCULATION, V93, P1043
[9]   Myalgic encephalomyelitis: International Consensus Criteria [J].
Carruthers, B. M. ;
van de Sande, M. I. ;
De Meirleir, K. L. ;
Klimas, N. G. ;
Broderick, G. ;
Mitchell, T. ;
Staines, D. ;
Powles, A. C. P. ;
Speight, N. ;
Vallings, R. ;
Bateman, L. ;
Baumgarten-Austrheim, B. ;
Bell, D. S. ;
Carlo-Stella, N. ;
Chia, J. ;
Darragh, A. ;
Jo, D. ;
Lewis, D. ;
Light, A. R. ;
Marshall-Gradisbik, S. ;
Mena, I. ;
Mikovits, J. A. ;
Miwa, K. ;
Murovska, M. ;
Pall, M. L. ;
Stevens, S. .
JOURNAL OF INTERNAL MEDICINE, 2011, 270 (04) :327-338
[10]  
Carruthers BM., 2003, J Chronic Fatigue Syndr, V11, P7, DOI [DOI 10.1300/J092V11N01_02, 10.1300/J092v11n01_02]