ROS/RNS and Base Dual Activatable Merocyanine-Based NIR-II Fluorescent Molecular Probe for in vivo Biosensing

被引：126

作者：

Zhang, Xin ^{[1
]}

Chen, Ying ^{[1
]}

He, Haisheng ^{[1
]}

Wang, Shangfeng ^{[1
]}

Lei, Zuhai ^{[2
]}

Zhang, Fan ^{[1
]}

机构：

[1] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat & iC, Dept Chem, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[2] Minist Educ, Key Lab Smart Drug Delivery, Sch Pharm, Shanghai 201203, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 50期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

biosensing; dual activation; merocyanine; molecular probe; second near-infrared window; INFLAMMATORY-BOWEL-DISEASE; HYDROGEN-PEROXIDE; LUMINAL PH; PATHOPHYSIOLOGY; DETERMINANTS; DESIGN; CANCER; FRET; DYE;

D O I：

10.1002/anie.202109728

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inflammation usually results in high-level reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only in acidic tissue but also in alkaline tissue. However, noninvasively in vivo monitoring reactive species specifically within alkaline tissue remains a huge challenge. Here we introduce a dual activatable fluorescent probe PN910 located in the second near-infrared window (NIR-II, 900-1700 nm), which shows high selectivity toward H2O2 and OONO- at pH beyond 7.4. Then we verified that PN910 could be used for the real-time, specific and accurate monitoring of cystitis and colitis for living animals. This report presents a unique approach to the development of dual activatable probe for in vivo biosensing.

引用

页码：26337 / 26341

页数：5

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