Protective antibodies and T cell responses to Omicron variant after the booster dose of BNT162b2 vaccine

被引：16

作者：

Naaber, Paul ^{[1
,2
]}

Tserel, Liina ^{[3
]}

Kangro, Kadri ^{[4
]}

Punapart, Marite ^{[5
]}

Sepp, Epp ^{[2
]}

Jurjenson, Virge ^{[1
]}

Karner, Jaanika ^{[3
]}

Haljasmagi, Liis ^{[3
]}

Haljasorg, Uku ^{[3
]}

Kuusk, Marilin ^{[4
]}

Sankovski, Eve ^{[4
]}

Planken, Anu ^{[4
,6
]}

Ustav, Mart ^{[4
]}

Zusinaite, Eva ^{[7
]}

Gerhold, Joachim M. ^{[4
]}

Kisand, Kai ^{[3
]}

Peterson, Part ^{[3
]}

机构：

[1] SYNLAB Estonia, Tallinn, Estonia

[2] Univ Tartu, Inst Biomed & Translat Med, Dept Microbiol, Tartu, Estonia

[3] Univ Tartu, Inst Biomed & Translat Med, Mol Pathol, Tartu, Estonia

[4] Icosagen Cell Factory, Ossu, Kambja, Estonia

[5] Univ Tartu, Biosafety Core Facil, Tartu, Estonia

[6] North Estonian Med Ctr, Dept Oncol, Tallinn, Estonia

[7] Univ Tartu, Inst Technol, Tartu, Estonia

来源：

CELL REPORTS MEDICINE | 2022年 / 3卷 / 08期

关键词：

SARS-COV-2;

D O I：

10.1016/j.xcrm.2022.100716

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The high number of mutations in the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes its immune escape. We report a longitudinal analysis of 111 vaccinated individuals for their antibody levels up to 6 months after the third dose of the BNT162b2 vaccine. After the third dose, the antibody levels decline but less than after the second dose. The booster dose remarkably increases the serum ability to block wild-type or Omicron variant spike protein's receptor-binding domain (RBD) inter-action with the angiotensin-converting enzyme 2 (ACE2) receptor, and these protective antibodies persist 3 months later. Three months after the booster dose, memory CD4(+) and CD8(+) T cells to the wild-type and Omicron variant are detectable in the majority of vaccinated individuals. Our data show that the third dose restores the high levels of blocking antibodies and enhances T cell responses to Omicron.

引用

页数：16

共 28 条

[1]

[Anonymous], 2021, Guidance for representative and targeted genomic SARS-COV-2 monitoring Internet

[2]

Cameroni E, 2022, NATURE, V602, P664, DOI [10.1038/s41586-021-04386-2, 10.1101/2021.12.12.472269]

[3] Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron [J].

Carreno, Juan Manuel ;

Alshammary, Hala ;

Tcheou, Johnstone ;

Singh, Gagandeep ;

Raskin, Ariel J. ;

Kawabata, Hisaaki ;

Sominsky, Levy A. ;

Clark, Jordan J. ;

Adelsberg, Daniel C. ;

Bielak, Dominika A. ;

Gonzalez-Reiche, Ana Silvia ;

Dambrauskas, Nicholas ;

Vigdorovich, Vladimir ;

Srivastava, Komal ;

Sather, D. Noah ;

Sordillo, Emilia Mia ;

Bajic, Goran ;

van Bakel, Harm ;

Simon, Viviana ;

Krammer, Florian .

NATURE, 2022, 602 (7898) :682-+

[4] Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization [J].

Cele, Sandile ;

Jackson, Laurelle ;

Khoury, David S. ;

Khan, Khadija ;

Moyo-Gwete, Thandeka ;

Tegally, Houriiyah ;

San, James Emmanuel ;

Cromer, Deborah ;

Scheepers, Cathrine ;

Amoako, Daniel G. ;

Karim, Farina ;

Bernstein, Mallory ;

Lustig, Gila ;

Archary, Derseree ;

Smith, Muneerah ;

Ganga, Yashica ;

Jule, Zesuliwe ;

Reedoy, Kajal ;

Hwa, Shi-Hsia ;

Giandhari, Jennifer ;

Blackburn, Jonathan M. ;

Gosnell, Bernadett, I ;

Karim, Salim S. Abdool ;

Hanekom, Willem ;

von Gottberg, Anne ;

Bhiman, Jinal N. ;

Lessells, Richard J. ;

Moosa, Mahomed-Yunus S. ;

Davenport, Miles P. ;

de Oliveira, Tulio ;

Moore, Penny L. ;

Sigal, Alex .

NATURE, 2022, 602 (7898) :654-+

[5] SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses [J].

Dejnirattisai, Wanwisa ;

Huo, Jiandong ;

Zhou, Daming ;

Zahradnik, Jiri ;

Supasa, Piyada ;

Liu, Chang ;

Duyvesteyn, Helen M. E. ;

Ginn, Helen M. ;

Mentzer, Alexander J. ;

Tuekprakhon, Aekkachai ;

Nutalai, Rungtiwa ;

Wang, Beibei ;

Dijokaite, Aiste ;

Khan, Suman ;

Avinoam, Ori ;

Bahar, Mohammad ;

Skelly, Donal ;

Adele, Sandra ;

Johnson, Sile Ann ;

Amini, Ali ;

Ritter, Thomas G. ;

Mason, Chris ;

Dold, Christina ;

Pan, Daniel ;

Assadi, Sara ;

Bellass, Adam ;

Omo-Dare, Nicola ;

Koeckerling, David ;

Flaxman, Amy ;

Jenkin, Daniel ;

Aley, Parvinder K. ;

Voysey, Merryn ;

Clemens, Sue Ann Costa ;

Naveca, Felipe Gomes ;

Nascimento, Valdinete ;

Nascimento, Fernanda ;

da Costa, Cristiano Fernandes ;

Resende, Paola Cristina ;

Pauvolid-Correa, Alex ;

Siqueira, Marilda M. ;

Baillie, Vicky ;

Serafin, Natali ;

Kwatra, Gaurav ;

Da Silva, Kelly ;

Madhi, Shabir A. ;

Nunes, Marta C. ;

Malik, Tariq ;

Openshaw, Peter J. M. ;

Baillie, J. Kenneth ;

Semple, Malcolm G. .

CELL, 2022, 185 (03) :467-+

[6] Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant [J].

Gao, Yu ;

Cai, Curtis ;

Grifoni, Alba ;

Muller, Thomas R. ;

Niessl, Julia ;

Olofsson, Anna ;

Humbert, Marion ;

Hansson, Lotta ;

Osterborg, Anders ;

Bergman, Peter ;

Chen, Puran ;

Olsson, Annika ;

Sandberg, Johan K. ;

Weiskopf, Daniela ;

Price, David A. ;

Ljunggren, Hans-Gustaf ;

Karlsson, Annika C. ;

Sette, Alessandro ;

Aleman, Soo ;

Buggert, Marcus .

NATURE MEDICINE, 2022, 28 (03) :472-+

[7]

Garcia-Beltran WF, 2022, CELL, V185, P457, DOI [10.1016/j.cell.2021.12.033, 10.1101/2021.12.14.21267755]

[8] Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients [J].

GeurtsvanKessel, Corine H. ;

Geers, Daryl ;

Schmitz, Katharina S. ;

Mykytyn, Anna Z. ;

Lamers, Mart M. ;

Bogers, Susanne ;

Scherbeijn, Sandra ;

Gommers, Lennert ;

Sablerolles, Roos S. G. ;

Nieuwkoop, Nella N. ;

Rijsbergen, Laurine C. ;

van Dijk, Laura L. A. ;

de Wilde, Janet ;

Alblas, Kimberley ;

Breugem, Tim, I ;

Rijnders, Bart J. A. ;

de Jager, Herbert ;

Weiskopf, Daniela ;

van der Kuy, P. Hugo M. ;

Sette, Alessandro ;

Koopmans, Marion P. G. ;

Grifoni, Alba ;

Haagmans, Bart L. ;

de Vries, Rory D. .

SCIENCE IMMUNOLOGY, 2022, 7 (69)

[9] mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern [J].

Goel, Rishi R. ;

Painter, Mark M. ;

Apostolidis, Sokratis A. ;

Mathew, Divij ;

Meng, Wenzhao ;

Rosenfeld, Aaron M. ;

Lundgreen, Kendall A. ;

Reynaldi, Arnold ;

Khoury, David S. ;

Pattekar, Ajinkya ;

Gouma, Sigrid ;

Kuri-Cervantes, Leticia ;

Hicks, Philip ;

Dysinger, Sarah ;

Hicks, Amanda ;

Sharma, Harsh ;

Herring, Sarah ;

Korte, Scott ;

Baxter, Amy E. ;

Oldridge, Derek A. ;

Giles, Josephine R. ;

Weirick, Madison E. ;

McAllister, Christopher M. ;

Awofolaju, Moses ;

Tanenbaum, Nicole ;

Drapeau, Elizabeth M. ;

Dougherty, Jeanette ;

Long, Sherea ;

D'Andrea, Kurt ;

Hamilton, Jacob T. ;

McLaughlin, Maura ;

Williams, Justine C. ;

Adamski, Sharon ;

Kuthuru, Oliva ;

Frank, Ian ;

Betts, Michael R. ;

Vella, Laura A. ;

Grifoni, Alba ;

Weiskopf, Daniela ;

Sette, Alessandro ;

Hensley, Scott E. ;

Davenport, Miles P. ;

Bates, Paul ;

Prak, Eline T. Luning ;

Greenplate, Allison R. ;

Wherry, E. John .

SCIENCE, 2021, 374 (6572) :1214-+

[10] Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals [J].

Grifoni, Alba ;

Weiskopf, Daniela ;

Ramirez, Sydney, I ;

Mateus, Jose ;

Dan, Jennifer M. ;

Moderbacher, Carolyn Rydyznski ;

Rawlings, Stephen A. ;

Sutherland, Aaron ;

Premkumar, Lakshmanane ;

Jadi, Ramesh S. ;

Marrama, Daniel ;

de Silva, Aravinda M. ;

Frazier, April ;

Carlin, Aaron F. ;

Greenbaum, Jason A. ;

Peters, Bjoern ;

Krammer, Florian ;

Smith, Davey M. ;

Crotty, Shane ;

Sette, Alessandro .

CELL, 2020, 181 (07) :1489-+

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