Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis

被引：2

作者：

Audouard, Emilie ^{[1
]}

Michel, Fanny ^{[2
]}

Pierroz, Vanessa ^{[2
]}

Kim, Taeuk ^{[2
]}

Rousselot, Lisa ^{[1
]}

Gillet-Legrand, Beatrix ^{[1
]}

Dufayet-Chauffaut, Gaelle ^{[1
]}

Buchmann, Peter ^{[2
]}

Florea, Michael ^{[2
]}

Khel, Alexander ^{[3
]}

Altynbekova, Kamilya ^{[3
]}

Delgaldo, Claudia ^{[4
]}

Escudero, Encarna ^{[4
]}

Soler, Alejandra Ben Aissa ^{[4
]}

Cartier, Nathalie ^{[1
]}

Piguet, Francoise ^{[1
]}

Folcher, Marc ^{[2
,5
]}

机构：

[1] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, NeuroGenCell,Paris Brain Inst,ICM,INSERM,CNRS, Paris, France

[2] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, D BSSE, Basel, Switzerland

[3] GeneXplain GmbH, Wolfenbuettel, Germany

[4] Ctr Tecnol Catalunya, Funct Printing & Embedded Devices Unit, Eurecat, Mataro, Spain

[5] IOB, Inst Mol & Clin Ophthalmol, Basel, Switzerland

来源：

JOURNAL OF CONTROLLED RELEASE | 2022年 / 352卷

关键词：

Cell-based device; Optogenetic; Bioelectronic; Drug delivery; Multiple sclerosis; Interferon; SYNTHETIC BIOLOGY; IFN-BETA; IN-VITRO; THERAPY; TECHNOLOGY; RELEASE; MICE;

D O I：

10.1016/j.jconrel.2022.11.008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-I3 delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-I3 production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based implant biocompatibility, and device performances were evaluated in the Experimental Autoimmune Encephalomyelitis (EAE) mouse model of multiple sclerosis.

引用

页码：994 / 1008

页数：15

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