Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy

被引：13

作者：

Hayashi, Naomi ^{[1
]}

Sato, Yasuyoshi ^{[1
]}

Fujiwara, Yu ^{[1
,2
]}

Fukuda, Naoki ^{[1
]}

Wang, Xiaofei ^{[1
]}

Nakano, Kenji ^{[1
]}

Urasaki, Testuya ^{[1
]}

Ohnnoto, Akihiro ^{[1
]}

Ono, Makiko ^{[1
]}

Tomomatsu, Junichi ^{[1
]}

Sato, Yukiko ^{[3
]}

Mitani, Hiroki ^{[4
]}

Toshiyasu, Takashi ^{[5
]}

Takahashi, Shunji ^{[1
]}

机构：

[1] Japanese Fdn Canc Res, Dept Med Oncol, Canc Inst Hosp, Tokyo, Japan

[2] Icahn Sch Med Mt Sinai, Dept Med, Mt Sinai Beth Israel, New York, NY 10029 USA

[3] Japanese Fdn Canc Res, Canc Inst Hosp, Pathol, Tokyo, Japan

[4] Japanese Fdn Canc Res, Canc Inst Hosp, Head & Neck Oncol, Tokyo, Japan

[5] Japanese Fdn Canc Res, Canc Inst Hosp, Radiat Oncol, Tokyo, Japan

来源：

CANCER MANAGEMENT AND RESEARCH | 2021年 / 13卷

关键词：

head and neck cancer; squamous cell carcinoma of head and neck; sarcopenia; cachexia; muscle; skeletal; chemoradiotherapy; prognosis; LOCALLY ADVANCED HEAD; SKELETAL-MUSCLE; MEGESTROL-ACETATE; SARCOPENIA; MASS; RADIOTHERAPY; PREVALENCE; OBESITY; AGE;

D O I：

10.2147/CMAR.S329581

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer. Patients and Methods: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settings, clinical outcomes were compared between cachexia and non-cachexia patients. Results: Forty patients were diagnosed with cachexia (20.8%). In the definitive setting, overall survival (OS) was significantly shorter in the cachexia group (3-year OS: 50.0% vs 88.5%; p < 0.01), and multivariate analysis identified UICC stage IV, baseline albumin of <4 and cachexia as poor prognostic factors. However, cachexia was not significant in the adjuvant setting. Conclusion: Cancer cachexia was negatively associated with prognosis in patients with HNC who received definitive chemoradiotherapy. Nutritional intervention during chemora-diotherapy may improve survival in these patients.

引用

页码：8377 / 8385

页数：9

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