Facile, Rapid, and High-Yield Synthesis of Pillar[5]arene from Commercially Available Reagents and Its X-ray Crystal Structure

被引：200

作者：

Ogoshi, Tomoki ^{[1
]}

Aoki, Takamichi ^{[1
]}

Kitajima, Keisuke ^{[1
]}

Fujinami, Shuhei ^{[1
]}

Yamagishi, Tada-aki ^{[1
]}

Nakamoto, Yoshiaki ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 9201192, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 01期

关键词：

ALPHA-CYCLODEXTRIN; POLYROTAXANE; ROTAXANE; COMPLEXATION; CUCURBITURIL; CALIXARENES; BEHAVIOR; POLYMER; DESIGN; GUEST;

D O I：

10.1021/jo1020823

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We monitored the progress of formation of dimethoxypillar[5]arene by size-exclusion chromatography. Surprisingly, the cyclization reaction completely finished in just 3 min. By improving the reaction conditions and purification process, we successfully obtained dimethoxypillar[5]arene in a short time and in high yield (71%) from commercially available reagents. By improving the deprotection reaction of the methoxy moieties, pillar[5]arene was isolated quantitatively. Single crystal X-ray analysis confirmed the structure of pillar[5]arene in the solid state.

引用

页码：328 / 331

页数：4

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