COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

被引：59

作者：

Abdukahil, Sheryl Ann ^{[1
]}

Abe, Ryuzo ^{[1
]}

Abel, Laurent ^{[1
]}

Absil, Lara ^{[1
]}

Acker, Andrew ^{[1
]}

Adachi, Shingo ^{[1
]}

Adam, Elisabeth ^{[1
]}

Adriao, Diana ^{[1
]}

Ainscough, Kate ^{[1
]}

Hssain, Ali Ait ^{[1
]}

Tamlihat, Younes Ait ^{[1
]}

Akimoto, Takako ^{[1
]}

Al-Dabbous, Tala ^{[1
]}

Al-Fares, Abdulrahman ^{[1
]}

Al Qasim, Eman ^{[1
]}

Alalqam, Razi ^{[1
]}

Alex, Beatrice ^{[1
]}

Alexandre, Kevin ^{[1
]}

Alfoudri, Huda ^{[1
]}

Alidjnou, Kazali Enagnon ^{[1
]}

Aliudin, Jeffrey ^{[1
]}

Allavena, Clotilde ^{[1
]}

Allou, Nathalie ^{[1
]}

Alves, Joao ^{[1
]}

Alves, Rita ^{[1
]}

Amaral, Maria ^{[1
]}

Ammerlaan, Heidi ^{[1
]}

Ampaw, Phoebe ^{[1
]}

Andini, Roberto ^{[1
]}

Andrejak, Claire ^{[1
]}

Angheben, Andrea ^{[1
]}

Angoulvant, Francois ^{[1
]}

Ansart, Severine ^{[1
]}

Antonelli, Massimo ^{[1
]}

De Brito, Carlos Alexandre Antunes ^{[1
]}

Arabi, Yaseen ^{[1
]}

Aragao, Irene ^{[1
]}

Arcadipane, Antonio ^{[1
]}

Arenz, Lukas ^{[1
]}

Arlet, Jean-Benoit ^{[1
]}

Arnold-Day, Christel ^{[1
]}

Arora, Lovkesh ^{[1
]}

Artaud-Macari, Elise ^{[1
]}

Asensio, Angel ^{[1
]}

Assie, Jean Baptiste ^{[1
]}

Atique, Anika ^{[1
]}

Auchabie, Johann ^{[1
]}

Aumaitre, Hugues ^{[1
]}

Azemar, Laurene ^{[1
]}

Azoulay, Cecile ^{[1
]}

机构：

[1] Univ Oxford, ISARIC Global Support Ctr, Ctr Trop Med & Global Hlth, New Richards Bldg,Old Rd Campus, Oxford OX3 7LG, England

来源：

INFECTION | 2021年 / 49卷 / 05期

基金：

英国医学研究理事会; 美国国家卫生研究院; 英国惠康基金; 加拿大健康研究院;

关键词：

Case definition; COVID-19; Diagnosis; SARS-CoV-2; Symptoms;

D O I：

10.1007/s15010-021-01599-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men. © 2021, The Author(s).

引用

页码：889 / 905

页数：17

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