Epidemiology of gestational diabetes mellitus according to IADPSG/WHO 2013 criteria among obese pregnant women in Europe

被引：119

作者：

Egan, Aoife M. ^{[1
]}

Vellinga, Akke ^{[1
]}

Harreiter, Juergen ^{[2
]}

Simmons, David ^{[3
,4
]}

Desoye, Gernot ^{[5
]}

Corcoy, Rosa ^{[6
,7
]}

Adelantado, Juan M. ^{[6
]}

Devlieger, Roland ^{[8
,9
]}

Van Assche, Andre ^{[8
,9
]}

Galjaard, Sander ^{[8
,9
,10
]}

Damm, Peter ^{[11
,12
,13
]}

Mathiesen, Elisabeth R. ^{[11
,12
,13
]}

Jensen, Dorte M. ^{[14
,15
,16
]}

Andersen, Liselotte ^{[14
,15
,16
]}

Lapolla, Annuziata ^{[17
]}

Dalfra, Maria G. ^{[17
]}

Bertolotto, Alessandra ^{[18
]}

Mantaj, Urszula ^{[19
]}

Wender-Ozegowska, Ewa ^{[19
]}

Zawiejska, Agnieszka ^{[19
]}

Hill, David ^{[20
]}

Jelsma, Judith G. M. ^{[21
]}

Snoek, Frank J. ^{[22
,23
]}

Worda, Christof ^{[24
]}

Bancher-Todesca, Dagmar ^{[24
]}

van Poppel, Mireille N. M. ^{[21
,25
]}

Kautzky-Willer, Alexandra ^{[2
]}

Dunne, Fidelma P. ^{[1
]}

机构：

[1] Natl Univ Ireland, Galway Diabet Res Ctr, Coll Med Nursing & Hlth Sci, Univ Rd, Galway H91 TK33, Ireland

[2] Med Univ Vienna, Div Endocrinol & Metab, Dept Med 3, Gender Med Unit, Vienna, Austria

[3] Addenbrookes Hosp, Inst Metab Sci, Cambridge, England

[4] Western Sydney Univ, Macarthur Clin Sch, Sydney, NSW, Australia

[5] Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria

[6] Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain

[7] Inst Salud Carlos III, CIBER Bioengn Biomat & Nanotechnol, Zaragoza, Spain

[8] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Dev & Regenerat Pregnancy Fetus & Neonate, Leuven, Belgium

[9] Univ Hosp Leuven, Gynaecol & Obstet, Leuven, Belgium

[10] Univ Med Ctr Rotterdam, Div Obstet & Prenatal Med, Dept Obstet & Gynaecol, Erasmus MC, Rotterdam, Netherlands

[11] Rigshosp, Ctr Pregnant Women Diabet, Dept Endocrinol, Copenhagen, Denmark

[12] Rigshosp, Ctr Pregnant Women Diabet, Dept Obstet, Copenhagen, Denmark

[13] Univ Copenhagen, Inst Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark

[14] Univ Southern Denmark, Odense Univ Hosp, Dept Endocrinol, Fac Hlth Sci, Odense, Denmark

[15] Univ Southern Denmark, Odense Univ Hosp, Dept Obstet & Gynaecol, Fac Hlth Sci, Odense, Denmark

[16] Univ Southern Denmark, Dept Clin Res, Fac Hlth Sci, Odense, Denmark

[17] Univ Padua, Padua, Italy

[18] Azienda Osped Univ Pisana, Pisa, Italy

[19] Poznan Univ Med Sci, Med Fac 1, Poznan, Poland

[20] Rech Sante Lawson SA, St Gallen, Switzerland

[21] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Publ & Occupat Hlth, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands

[22] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Med Psychol, Amsterdam, Netherlands

[23] Med Psychol AMC, Amsterdam, Netherlands

[24] Med Univ Vienna, Div Obstet & Fetomaternal Med, Dept Obstet & Gynecol, Vienna, Austria

[25] Karl Franzens Univ Graz, Inst Sports Sci, Graz, Austria

来源：

DIABETOLOGIA | 2017年 / 60卷 / 10期

关键词：

Clinical diabetes; Clinical science and care; Epidemiology; Healthcare delivery; Pregnancy; Weight regulation and obesity; DALI LIFE-STYLE; INTERNATIONAL ASSOCIATION; INSULIN SENSITIVITY; GLUCOSE-TOLERANCE; HYPERGLYCEMIA; DIAGNOSIS; CLASSIFICATION; CIRCUMFERENCE; MULTICENTER; GYNECOLOGY;

D O I：

10.1007/s00125-017-4353-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/hypothesis Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic criteria and screening strategies in both high-risk women and the general pregnant population. Our aims were to report important risk factors for GDM development and calculate the prevalence of GDMin a cohort of women withBMI >= 29 kg/m(2) across 11 centres in Europe using the International Association of the Diabetes and Pregnancy Study Groups (IADPSG)/WHO 2013 diagnostic criteria. Methods Pregnant women (n = 1023, 86.3% European ethnicity) with a BMI = 29.0 kg/m(2) enrolled into the Vitamin D and Lifestyle Intervention for GDM Prevention (DALI) pilot, lifestyle and vitamin D studies of this pan-European multicentre trial, attended for an OGTT during pregnancy. Demographic, anthropometric and metabolic data were collected at enrolment and throughout pregnancy. GDM was diagnosed using IADPSG/WHO 2013 criteria. GDM treatment followed local policies. Results The number of women recruited per country ranged from 80 to 217, and the dropout rate was 7.1%. Overall, 39% of women developed GDM during pregnancy, with no significant differences in prevalence across countries. The prevalence of GDM was high (24%; 242/1023) in early pregnancy. Despite interventions used in the DALI study, a further 14% (94/672) had developed GDM when tested at mid gestation (24-28 weeks) and 13% (59/476) of the remaining cohort at late gestation (35-37 weeks). Demographics and lifestyle factors were similar at baseline between women with GDM and those who maintained normal glucose tolerance. Previous GDM (16.5% vs 7.9%, p = 0.002), congenital malformations (6.4% vs 3.3%, p = 0.045) and a baby with macrosomia (31.4% vs 17.9%, p = 0.001) were reported more frequently in those who developed GDM. Significant anthropometric and metabolic differences were already present in early pregnancy between women who developed GDM and those who did not. Conclusions/interpretation The prevalence of GDM diagnosed by the IADPSG/WHO 2013 GDM criteria in European pregnant women with a BMI >= 29.0 kg/m(2) is substantial, and poses a significant health burden to these pregnancies and to the future health of the mother and her offspring. Uniform criteria for GDM diagnosis, supported by robust evidence for the benefits of treatment, are urgently needed to guide modern GDM screening and treatment strategies.

引用

页码：1913 / 1921

页数：9

共 31 条

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[Anonymous], 2013, Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy

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