Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes

被引：37

作者：

Nordgard, Silje H. ^{[1
,2
]}

Johansen, Fredrik E. ^{[1
]}

Alnaes, Grethe I. G. ^{[1
]}

Naume, Bjorn ^{[3
]}

Borresen-Dale, Anne-Lise ^{[1
,2
]}

Kristensen, Vessela N. ^{[1
,2
]}

机构：

[1] Natl Hosp Norway, Radiumhosp, Med Ctr, Inst Canc Res,Dept Genet, N-0310 Oslo, Norway

[2] Natl Hosp Norway, Radiumhosp, Med Ctr, N-0310 Oslo, Norway

[3] Univ Oslo, Fac Med, N-0310 Oslo, Norway

来源：

BREAST CANCER RESEARCH | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1186/bcr1784

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, genome-wide association studies of breast cancer revealed single nucleotide polymorphisms ( SNPs) in five genes with novel association to susceptibility. While there is little doubt that the novel susceptibility markers produced from such highly powered studies are true, the mechanisms by which they cause the susceptibility remain undetermined. We have looked at the expression levels of the identified genes in tumours and found that they are highly significantly differentially expressed between the five established breast cancer subtypes. Also, a significant association between SNPs in these genes and their expression in tumours was seen as well as a significantly different frequency of the SNPs between the subtypes. This suggests that the observed genes are associated with different breast cancer subtypes, and may exert their effect through their expression in the tumours. Thus, future studies stratifying patients by their molecular subtypes may give much more power to classic case control studies, and genes of no or borderline significance may appear to be high-penetrant for certain subtypes and, therefore, be identifiable.

引用

页数：2

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