The role of GSK3 in glucose homeostasis and the development of insulin resistance

被引：179
|
作者：
Lee, Jongsoon [1 ]
Kim, Myung-Sunny [1 ]
机构：
[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2007年 / 77卷
关键词：
GSK3; insulin signaling; glucose homeostasis;
D O I：
10.1016/j.diabres.2007.01.033
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
GSK3 has been implicated in the development of insulin resistance, primarily based on its role in regulation of glycogen synthesis. However. GSK3 is involved in many other important signaling cascades which may regulate glucose homeostasis and the development of insulin resistance. In addition, GSK3 is composed of two isoforms, GSK3 alpha and beta, which do not completely share their physiological roles, and this raises a possibility that GSK3 alpha and beta may function differently in glucose homeostasis. In this review, we will give an overview to examine potential mechanisms for the roles of GSK3 in the development of insulin resistance. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：S49 / S57
页数：9
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