Carboxymethylcellulose capsulated Cu-based metal-organic framework-drug nanohybrid as a pH-sensitive nanocomposite for ibuprofen oral delivery

被引:145
作者
Javanbakht, Siamak [1 ]
Pooresmaeil, Malihe [1 ]
Hashemi, Hamed [1 ]
Namazi, Hassan [1 ,2 ]
机构
[1] Univ Tabriz, Res Lab Dendrimers & Nanopolymers, Fac Chem, Tabriz, Iran
[2] Tabriz Univ Med Sci, RCPN, Tabriz, Iran
关键词
Metal-organic framework; Carboxymethylcellulose; Hydrogel; Oral delivery; Controlled release; HYDROGEL BEADS; ANTICANCER DRUG; NANOPARTICLES; CELLULOSE; CARRIERS; RELEASE; BEHAVIOR; ENCAPSULATION; DOXORUBICIN; COMPOSITES;
D O I
10.1016/j.ijbiomac.2018.07.181
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Due to non-invasive nature of oral delivery and the fact that avoids patient pain and discomfort, so the oral method is one of the most commonly used. By consideration this aim, Cu-based metal-organic framework encapsulated ibuprofen (IBU) drug nanohybrid (Cu-MOF@Drug) protected with pH-sensitive biopolymeric carboxymethylcellulose (CMC) as a novel nanocomposite for oral delivery system was synthesized. The prepared hydrogel bead characterized using FT-IR, BET, XRD, UV-Vis spectroscopy and SEM analysis. The drug release tests showed that the CMC capsulated Cu-MOF@IBU nanocomposite hydrogel bead (CMC/Cu-MOF@IBU) has a better protection against stomach pH and extended the stability of drug dosing indeed it provides a controlled release in the gastrointestinal tract conditions. The MTT test demonstrated that the CMC/Cu-MOF@IBU has low toxicity against Caco-2 cells. According to the obtained results, the hydrogel bead could potentially use as an oral drug delivery system. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码:588 / 596
页数:9
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