Unusual C25 steroids produced by a sponge-derived Penicillium citrinum

被引：93
作者：
Amagata, T [1 ]
Amagata, A
Tenney, K
Valeriote, FA
Lobkovsky, E
Clardy, J
Crews, P
机构：
[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA
[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA
[3] Josephine Ford Canc Ctr, Detroit, MI 48202 USA
[4] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA
[5] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 23期
关键词：
D O I：
10.1021/ol0356800
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Structurally unique steroids, isocyclocitrinol A (1) and 22-acetylisocyclocitrinol A (2), were isolated from the extract of a saltwater culture of sponge-derived Penicilliun citrinum. The structures were established by analysis of 1D and 2D NMR data. The absolute structures were determined on the basis of X-ray structure analysis and application of modified Mosher's method. Furthermore, the structure of cyclocitrinol (3a) previously isolated from a terrestrial P. citrinum was revised as 3b. Compounds 1 and 2 showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans.
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页码：4393 / 4396
页数：4
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