Epigenetics in Alzheimer's Disease

被引：39
作者：
Gao, Xiaodie [1 ,2 ]
Chen, Qiang [2 ]
Yao, Hua [1 ]
Tan, Jie [1 ]
Liu, Zheng [1 ]
Zhou, Yan [1 ]
Zou, Zhenyou [1 ,2 ]
机构：
[1] Guilin Med Univ, Guangxi Key Lab Brain & Cognit Neurosci, Guilin, Peoples R China
[2] Brain Hosp Guangxi Zhuang Autonomous Reg, Dept Sci Res, Liuzhou, Peoples R China
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2022年 / 14卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; epigenetics; methylation; acetylation; ubiquitination; MILD COGNITIVE IMPAIRMENT; BRAIN DNA METHYLATION; MEMORY FORMATION; AMYLOID-BETA; EXTRACELLULAR HISTONES; GENE-EXPRESSION; NONCODING RNAS; GLOBAL CHANGES; A-BETA; 5-HYDROXYMETHYLCYTOSINE;
D O I：
10.3389/fnagi.2022.911635
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and complex pathological manifestations. At present, a large number of studies on targeted drugs for the typical pathological phenomenon of AD (A beta) have ended in failure. Although there are some drugs on the market that indirectly act on AD, their efficacy is very low and the side effects are substantial, so there is an urgent need to develop a new strategy for the treatment of AD. An increasing number of studies have confirmed epigenetic changes in AD. Although it is not clear whether these epigenetic changes are the cause or result of AD, they provide a new avenue of treatment for medical researchers worldwide. This article summarizes various epigenetic changes in AD, including DNA methylation, histone modification and miRNA, and concludes that epigenetics has great potential as a new target for the treatment of AD.
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页数：13
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