Isotretinoin for the treatment of nonobstructive azoospermia: a pilot study

被引：8
作者：
Amory, John K. [1 ]
Muller, Charles H. [2 ]
Walsh, Thomas J. [2 ]
机构：
[1] Univ Washington, Dept Med, Seattle, WA 98195 USA
[2] Univ Washington, Dept Urol, Seattle, WA 98195 USA
来源：
ASIAN JOURNAL OF ANDROLOGY | 2021年 / 23卷 / 05期
关键词：
SPERM; MEN; TISSUE;
D O I：
10.4103/aja.aja_18_21
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
The treatment of men with infertility from azoospermia is challenging. As some men with severe oligozoospermia improve sperm output during treatment with isotretinoin, we treated nine men with azoospermia with isotretinoin to determine if azoospermic men would also respond to isotretinoin treatment. One of these men who had a previous negative testicular sperm extraction (TESE) was found to have an area of sperm production on a postisotretinoin testicular extraction. This man achieved a pregnancy and a live birth of a healthy, term daughter after in vitro fertilization coupled with intracytoplasmic sperm injection (IVF/ICSI). A second subject had a positive TESE after treatment as well. Additional study of isotretinoin therapy in men with azoospermia undergoing testicular sperm harvesting procedures is warranted.
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收藏
页码：537 / 540
页数：4
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