Strategies for terpenoid overproduction and new terpenoid discovery

被引：89

作者：

Bian, Guangkai ^{[1
,2
]}

Deng, Zixin ^{[1
,2
,3
]}

Liu, Tiangang ^{[1
,2
,3
]}

机构：

[1] Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Hubei, Peoples R China

[2] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China

[3] Wuhan Inst Biotechnol, Hubei Engn Lab Synthet Microbiol, Wuhan 430075, Hubei, Peoples R China

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2017年 / 48卷

基金：

中国国家自然科学基金;

关键词：

IN-VITRO RECONSTITUTION; SACCHAROMYCES-CEREVISIAE; LYCOPENE OVERPRODUCTION; MEVALONATE PATHWAY; METABOLIC PATHWAYS; ESCHERICHIA-COLI; BIOSYNTHESIS; SYNTHASES; IDENTIFICATION; OPTIMIZATION;

D O I：

10.1016/j.copbio.2017.07.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Terpenoids comprise the largest family of natural products and have widespread applications. The overproduction of value-added terpenoids and the efficient mining of new terpenoids represent major challenges in the fields of metabolic engineering and natural product discovery. For terpenoid overproduction in microbial systems, in vitro reconstitution strategy guided rational engineering was emphasized, and -omics studies provide further information for targeted engineering. In addition, systematic engineering, including host and pathway engineering for terpenoid overproduction was reviewed. Furthermore, robust precursor supplies with optimized high-production hosts can also be used as an efficient platform to rapidly screen terpene cyclases and accelerate the process of mining new terpenoids.

引用

页码：234 / 241

页数：8

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