Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis

被引:6
作者
Qin, Jielin [1 ]
Yang, Han [2 ]
Shan, Zhiming [3 ]
Jiang, Lingzhi [4 ]
Zhang, Qingxian [1 ]
机构
[1] Zhengzhou Univ, Dept Gen Med, Dept Respirat & Intens Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R China
[2] Zhengzhou Univ, Dept Hepatobiliary & Pancreat Surg, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R China
[3] Zhengzhou Univ, Henan Childrens Hosp, Zhengzhou Childrens Hosp, Lab Dept,Childrens Hosp,Zhengzhou Children Infect, Zhengzhou 450000, Henan, Peoples R China
[4] Zhengzhou Univ, Dept Nephrol, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R China
关键词
antifungal drugs; Candida parapsilosis; clinical efficacy; meta-analysis; safety; LIPOSOMAL AMPHOTERICIN-B; BLOOD-STREAM INFECTIONS; FLUCONAZOLE; EPIDEMIOLOGY; CASPOFUNGIN; MICAFUNGIN; OUTBREAK; SURVEILLANCE; FUNGEMIA;
D O I
10.1099/jmm.0.001434
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Antifungal drugs have already been established as an effective treatment option for Candida parapsilosis infections, but there is no universal consensus on the ideal target for clinical efficacy and safety of antifungal drugs for the treatment of C. parapsilosis infections. Few studies have directly compared the efficacies of antifungal drugs for the treatment of C. parapsilosis infections. We hypothesize that different antifungal drugs offer differing clinical efficacy and safety for the treatment of C. parapsilosis infections. We performed a comprehensive network meta- analysis on different strategies for C. parapsilosis infection treatment and compared the clinical efficacy and safety of antifungal drugs as interventions for C. parapsilosis infections. The Cochrane Database of Systematic Reviews, Medline, Embase, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Technology of Chongqing VIP database, Wan Fang Data, and SinoMed databases were searched to identify appropriate randomized trials. Among the extracted C. parapsilosis cases, the survival and death rates with treatment of C. parapsilosis infection were compared among groups treated with different antifungal drugs. According to the evidence- network analysis, echinocandins were a better choice than other drugs for treating C. parapsilosis infections, and more importantly, caspofungin showed a more preferable effect for decreasing the risk of 30 day mortality. In conclusion, this study systematically evaluated the effectiveness and safety of antifungal drugs for the purpose of helping clinicians choose the most appropriate antifungal drugs. Future studies with larger samples are needed to evaluate the effects of patient factors on the clinical efficacy and safety of antifungal drugs for C. parapsilosis infections.
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页数:8
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共 34 条
[1]   Epidemiology, risk factors, and prognosis of Candida parapsilosis bloodstream infections:: Case-control population-based surveillance study of patients in Barcelona, Spain, from 2002 to 2003 [J].
Almirante, Benito ;
Rodríguez, Dolors ;
Cuenca-Estrella, Manuel ;
Almela, Manel ;
Sanchez, Ferran ;
Ayats, Josefina ;
Alonso-Tarres, Carles ;
Rodriguez-Tudela, Juan L. ;
Pahissa, Albert .
JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (05) :1681-1685
[2]   High frequency of Candida parapsilosis on the hands of healthy hosts [J].
Bonassoli, LA ;
Bertoli, M ;
Svidzinski, TIE .
JOURNAL OF HOSPITAL INFECTION, 2005, 59 (02) :159-162
[3]   Characterization of Candida parapsilosis complex strains isolated from invasive fungal infections [J].
Borghi, E. ;
Sciota, R. ;
Iatta, R. ;
Biassoni, C. ;
Montagna, M. T. ;
Morace, G. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2011, 30 (11) :1437-1441
[4]   Candida BLOODSTREAM INFECTION: DATA FROM A TEACHING HOSPITAL IN MATO GROSSO DO SUL, BRAZIL [J].
Chang, Marilene Rodrigues ;
Correia, Flavia Patussi ;
Costa, Leonora Correa ;
Niz Xavier, Paula Cristhina ;
Palhares, Durval Batista ;
Taira, Deborah Ledesma ;
Miranda Paniago, Anamaria Mello ;
Jardim Cury Pontes, Elenir Rose ;
Machado, Vanessa Escobar .
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, 2008, 50 (05) :265-268
[5]  
Chen JF, 2015, CHINESE J CLIN PHARM, V9
[6]   Therapeutic armamentarium against systemic fungal infections [J].
Cisneros Herreros, J. M. ;
Cordero Matia, E. .
CLINICAL MICROBIOLOGY AND INFECTION, 2006, 12 :53-64
[7]   Epidemiologic and molecular characterization of an outbreak of Candida parapsilosis bloodstream infections in a community hospital [J].
Clark, TA ;
Slavinski, SA ;
Morgan, J ;
Lott, T ;
Arthington-Skaggs, BA ;
Brandt, ME ;
Webb, RM ;
Currier, M ;
Flowers, RH ;
Fridkin, SK ;
Hajjeh, RA .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (10) :4468-4472
[8]   Global distribution and outcomes for Candida species causing invasive candidiasis:: Results from an international randomized double-blind study of caspofungin versus amphotericin B for the treatment of invasive candidiasis [J].
Colombo, AL ;
Perfect, J ;
DiNubile, M ;
Bartizal, K ;
Motyl, M ;
Hicks, P ;
Lupinacci, R ;
Sable, C ;
Kartsonis, N .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2003, 22 (08) :470-474
[9]  
Feng JW, 2007, CHINA TROPICAL MED, V39, P574
[10]   Systematic review and mixed treatment comparison of randomized evidence for empirical, pre-emptive and directed treatment strategies for invasive mould disease [J].
Freemantle, Nick ;
Tharmanathan, Puvan ;
Herbrecht, Raoul .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 :i25-i35