Evidence and Practicalities of Aqueous Sublingual Immunotherapy, Tablet Sublingual Immunotherapy, and Oral Mucosal Immunotherapy for Allergic Rhinitis and Allergic Asthma

被引：0

作者：

Roxbury, Christopher R. ^{[1
]}

Lin, Sandra Y. ^{[2
]}

机构：

[1] Univ Chicago Med & Biol Sci, Dept Surg, Sect Otolaryngol Head & Neck Surg, Chicago, IL USA

[2] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St,6th Floor, Baltimore, MD 21287 USA

来源：

CURRENT OTORHINOLARYNGOLOGY REPORTS | 2020年 / 8卷 / 01期

关键词：

Allergic rhinitis; Allergic asthma; Allergen immunotherapy; Sublingual immunotherapy; Oral mucosal immunotherapy; RANDOMIZED CONTROLLED-TRIAL; MILD PERSISTENT ASTHMA; DUST-MITE ALLERGEN; INTERNATIONAL CONSENSUS; DOUBLE-BLIND; EAACI GUIDELINES; UNITED-STATES; EFFICACY; SAFETY; ADULTS;

D O I：

10.1007/s40136-020-00268-9

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Purpose of ReviewAllergen immunotherapy (AIT) is the only disease-modifying treatment for allergic rhinitis (AR). Multiple modalities of AIT dosed via sublingual or oral routes are becoming available. This review discusses current evidence and practicalities of aqueous and tablet sublingual immunotherapy (SLIT) and oral mucosal immunotherapy (OMIT) in the treatment of AR and allergic asthma.Recent FindingsSeveral large-scale studies demonstrate the efficacy and safety of SLIT. These studies have led to the United States Food and Drug Administration (USFDA) approval of tablet SLIT against grass, ragweed, and house dust mites (HDM). However, off-label use of aqueous SLIT is still practiced as a safe and effective alternative in polysensitized patients. Growing evidence suggests a role for SLIT in patients with allergic asthma.SummaryThe literature supports the efficacy and safety of aqueous and tablet SLIT for AR, while some controversy remains over the utility of SLIT for allergic asthma. OMIT is currently in the early stages of development.

引用

页码：7 / 13

页数：7

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