Key signaling nodes in mammary gland development and cancer: β-catenin

被引：113
作者：
Incassati, Angela [1 ,2 ]
Chandramouli, Anupama [1 ,2 ]
Eelkema, Rachel [1 ,2 ]
Cowin, Pamela [1 ,2 ]
机构：
[1] NYU, Dept Cell Biol, Sch Med, New York, NY 10016 USA
[2] NYU, Dept Dermatol, Sch Med, New York, NY 10016 USA
来源：
BREAST CANCER RESEARCH | 2010年 / 12卷 / 06期
关键词：
HUMAN BREAST-CANCER; HORMONE-RELATED PROTEIN; APC GENE PROMOTER; INVASIVE-DUCTAL-CARCINOMA; E-CADHERIN; UP-REGULATION; WNT PATHWAY; PARATHYROID-HORMONE; PROGENITOR CELLS; CYCLIN D1;
D O I：
10.1186/bcr2723
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
beta-Catenin plays important roles in mammary development and tumorigenesis through its functions in cell adhesion, signal transduction and regulation of cell-context-specific gene expression. Studies in mice have highlighted the critical role of beta-catenin signaling for stem cell biology at multiple stages of mammary development. Deregulated beta-catenin signaling disturbs stem and progenitor cell dynamics and induces mammary tumors in mice. Recent data showing deregulated beta-catenin signaling in metaplastic and basal-type tumors suggest a similar link to reactivated developmental pathways and human breast cancer. The present review will discuss beta-catenin as a central transducer of numerous signaling pathways and its role in mammary development and breast cancer.
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页数：14
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