Key signaling nodes in mammary gland development and cancer: β-catenin

被引：113

作者：

Incassati, Angela ^{[1
,2
]}

Chandramouli, Anupama ^{[1
,2
]}

Eelkema, Rachel ^{[1
,2
]}

Cowin, Pamela ^{[1
,2
]}

机构：

[1] NYU, Dept Cell Biol, Sch Med, New York, NY 10016 USA

[2] NYU, Dept Dermatol, Sch Med, New York, NY 10016 USA

来源：

BREAST CANCER RESEARCH | 2010年 / 12卷 / 06期

关键词：

HUMAN BREAST-CANCER; HORMONE-RELATED PROTEIN; APC GENE PROMOTER; INVASIVE-DUCTAL-CARCINOMA; E-CADHERIN; UP-REGULATION; WNT PATHWAY; PARATHYROID-HORMONE; PROGENITOR CELLS; CYCLIN D1;

D O I：

10.1186/bcr2723

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

beta-Catenin plays important roles in mammary development and tumorigenesis through its functions in cell adhesion, signal transduction and regulation of cell-context-specific gene expression. Studies in mice have highlighted the critical role of beta-catenin signaling for stem cell biology at multiple stages of mammary development. Deregulated beta-catenin signaling disturbs stem and progenitor cell dynamics and induces mammary tumors in mice. Recent data showing deregulated beta-catenin signaling in metaplastic and basal-type tumors suggest a similar link to reactivated developmental pathways and human breast cancer. The present review will discuss beta-catenin as a central transducer of numerous signaling pathways and its role in mammary development and breast cancer.

引用

页数：14

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