Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

被引：22

作者：

Meixiong, James ^{[1
]}

Basso, Lilian ^{[2
]}

Dong, Xinzhong ^{[1
,3
]}

Gaudenzio, Nicolas ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Ctr Sensory Biol, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] Univ Toulouse, Unite Differenciat Epitheliale & Autoimmunite Rhu, INSERM, UMR 1056, F-31059 Toulouse, France

[3] Johns Hopkins Univ, Howard Hughes Med Inst, Sch Med, Baltimore, MD 21205 USA

来源：

TRENDS IN NEUROSCIENCES | 2020年 / 43卷 / 03期

基金：

欧洲研究理事会;

关键词：

D O I：

10.1016/j.tins.2020.01.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.

引用

页码：130 / 132

页数：4

共 12 条

[1] Small-Molecule Host-Defense Peptide Mimetic Antibacterial and Antifungal Agents Activate Human and Mouse Mast Cells via Mas-Related GPCRs
Alkanfari, Ibrahim
Freeman, Katie B.
Roy, Saptarshi
Jahan, Tahsin
Scott, Richard W.
Ali, Hydar
[J]. CELLS, 2019, 8 (04)
[2] MAST CELL/NERVE INTERACTIONS INVITRO AND INVIVO
BIENENSTOCK, J
MACQUEEN, G
SESTINI, P
MARSHALL, JS
STEAD, RH
PERDUE, MH
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 143 (03): : S55 - S58
[3] Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity
Cohen, Jonathan A.
Edwards, Tara N.
Liu, Andrew W.
Hirai, Toshiro
Jones, Marsha Ritter
Wu, Jianing
Li, Yao
Zhang, Shiqun
Ho, Jonhan
Davis, Brian M.
Albers, Kathryn M.
Kaplan, Daniel H.
[J]. CELL, 2019, 178 (04) : 919 - +
[4] Different activation signals induce distinct mast cell degranulation strategies
Gaudenzio, Nicolas
Sibilano, Riccardo
Marichal, Thomas
Starkl, Philipp
Reber, Laurent L.
Cenac, Nicolas
McNeil, Benjamin D.
Dong, Xinzhong
Hernandez, Joseph D.
Sagi-Eisenberg, Ronit
Hammel, Ilan
Roers, Axel
Valitutti, Salvatore
Tsai, Mindy
Espinosa, Eric
Galli, Stephen J.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (10) : 3981 - 3998
[5] A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain
Green, Dustin P.
Limjunyawong, Nathachit
Gour, Naina
Pundir, Priyanka
Dong, Xinzhong
[J]. NEURON, 2019, 101 (03) : 412 - +
[6] Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity
Kashem, Sakeen W.
Riedl, Maureen S.
Yao, Chen
Honda, Christopher N.
Vulchanova, Lucy
Kaplan, Daniel H.
[J]. IMMUNITY, 2015, 43 (03) : 515 - 526
[7] Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions
McNeil, Benjamin D.
Pundir, Priyanka
Meeker, Sonya
Han, Liang
Undem, Bradley J.
Kulka, Marianna
Dong, Xinzhong
[J]. NATURE, 2015, 519 (7542) : 237 - +
[8] Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch
Meixiong, James
Anderson, Michael
Limjunyawong, Nathachit
Sabbagh, Mark F.
Hu, Eric
Mack, Madison R.
Oetjen, Landon K.
Wang, Fang
Kim, Brian S.
Dong, Xinzhong
[J]. IMMUNITY, 2019, 50 (05) : 1163 - +
[9] Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation
Riol-Blanco, Lorena
Ordovas-Montanes, Jose
Perro, Mario
Naval, Elena
Thiriot, Aude
Alvarez, David
Paust, Silke
Wood, John N.
von Andrian, Ulrich H.
[J]. NATURE, 2014, 510 (7503) : 157 - +
[10] House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation
Serhan, Nadine
Basso, Lilian
Sibilano, Riccardo
Petitfils, Camille
Meixiong, James
Bonnart, Chrystelle
Reber, Laurent L.
Marichal, Thomas
Starkl, Philipp
Cenac, Nicolas
Dong, Xinzhong
Tsai, Mindy
Galli, Stephen J.
Gaudenzio, Nicolas
[J]. NATURE IMMUNOLOGY, 2019, 20 (11) : 1435 - +

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