Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

被引：24

作者：

Meixiong, James ^{[1
]}

Basso, Lilian ^{[2
]}

Dong, Xinzhong ^{[1
,3
]}

Gaudenzio, Nicolas ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Ctr Sensory Biol, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] Univ Toulouse, Unite Differenciat Epitheliale & Autoimmunite Rhu, INSERM, UMR 1056, F-31059 Toulouse, France

[3] Johns Hopkins Univ, Howard Hughes Med Inst, Sch Med, Baltimore, MD 21205 USA

来源：

TRENDS IN NEUROSCIENCES | 2020年 / 43卷 / 03期

基金：

欧洲研究理事会;

关键词：

D O I：

10.1016/j.tins.2020.01.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.

引用

页码：130 / 132

页数：4

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