FLASH radiotherapy with photon beams

被引：68

作者：

Montay-Gruel, Pierre ^{[1
,7
]}

Corde, Stephanie ^{[2
,3
,4
]}

Laissue, Jean A. ^{[5
]}

Bazalova-Carter, Magdalena ^{[6
]}

机构：

[1] Univ Calif Irvine, Dept Radiat Oncol, Irvine, CA USA

[2] Prince Wales Hosp, Dept Radiat Oncol, Randwick, NSW, Australia

[3] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW, Australia

[4] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia

[5] Univ Bern, Inst Pathol, Bern, Switzerland

[6] Univ Victoria, Dept Phys & Astron, Victoria, BC, Canada

[7] Iridium Network, Dept Radiotherapy, Antwerp, Belgium

来源：

MEDICAL PHYSICS | 2022年 / 49卷 / 03期

基金：

瑞士国家科学基金会; 英国医学研究理事会;

关键词：

FLASH-RT; radiotherapy; X-rays; MICROBEAM RADIATION-THERAPY; SYNCHROTRON MICROBEAM; LINEAR-ACCELERATOR; DOSE-RATE; IN-VIVO; DOSIMETRY; IRRADIATION; CELLS;

D O I：

10.1002/mp.15222

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Ultra-high-dose rate "FLASH" radiotherapy (FLASH-RT) has been shown to drastically reduce normal tissue toxicities while being as efficacious as conventional dose rate radiotherapy to treat tumors. A large number of preclinical studies describing this so-called FLASH effect have led to the clinical translation of FLASH-RT using ultra-high-dose rate electron and proton beams. Although the vast majority of radiation therapy treatments are delivered using X-rays, few preclinical data using ultra-high-dose rate X-ray irradiation have been published. This review focuses on different methods that can be used to generate ultra-high-dose rate X-rays and their beam characteristics along with their effect on the biological tissues and the perspectives for the development of FLASH-RT with X-rays.

引用

页码：2055 / 2067

页数：13

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