FLASH radiotherapy with photon beams

被引：68
作者：
Montay-Gruel, Pierre [1 ,7 ]
Corde, Stephanie [2 ,3 ,4 ]
Laissue, Jean A. [5 ]
Bazalova-Carter, Magdalena [6 ]
机构：
[1] Univ Calif Irvine, Dept Radiat Oncol, Irvine, CA USA
[2] Prince Wales Hosp, Dept Radiat Oncol, Randwick, NSW, Australia
[3] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW, Australia
[4] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia
[5] Univ Bern, Inst Pathol, Bern, Switzerland
[6] Univ Victoria, Dept Phys & Astron, Victoria, BC, Canada
[7] Iridium Network, Dept Radiotherapy, Antwerp, Belgium
来源：
MEDICAL PHYSICS | 2022年 / 49卷 / 03期
基金：
瑞士国家科学基金会; 英国医学研究理事会;
关键词：
FLASH-RT; radiotherapy; X-rays; MICROBEAM RADIATION-THERAPY; SYNCHROTRON MICROBEAM; LINEAR-ACCELERATOR; DOSE-RATE; IN-VIVO; DOSIMETRY; IRRADIATION; CELLS;
D O I：
10.1002/mp.15222
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Ultra-high-dose rate "FLASH" radiotherapy (FLASH-RT) has been shown to drastically reduce normal tissue toxicities while being as efficacious as conventional dose rate radiotherapy to treat tumors. A large number of preclinical studies describing this so-called FLASH effect have led to the clinical translation of FLASH-RT using ultra-high-dose rate electron and proton beams. Although the vast majority of radiation therapy treatments are delivered using X-rays, few preclinical data using ultra-high-dose rate X-ray irradiation have been published. This review focuses on different methods that can be used to generate ultra-high-dose rate X-rays and their beam characteristics along with their effect on the biological tissues and the perspectives for the development of FLASH-RT with X-rays.
引用
收藏
页码：2055 / 2067
页数：13
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