Synthesis of [14C]-imexon

被引：2
作者：
Jagadish, B
Iyengar, BS
Sólyom, AM
Remers, WA
Dorr, RT
Yu, JS
Gupta, S
Mash, EA [1 ]
机构：
[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA
[2] Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA
[3] Univ Arizona, Dept Pharmacol, Tucson, AZ 85721 USA
[4] Amer Radiolabeled Chem Inc, St Louis, MO 63146 USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2005年 / 48卷 / 03期
关键词：
imexon; aziridine; sulfhydryl-binding; anticancer agent;
D O I：
10.1002/jlcr.911
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A four-step synthesis of [C-14]-imexon is described, starting from [C-14]-phosgene. The overall yield is 27% and the specific activity is 55 mCi/mmol. Copyright (c) 2005 John Wiley & Sons, Ltd.
引用
收藏
页码：165 / 170
页数：6
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