Novel jadomycins: incorporation of non-natural and natural amino acids

被引：34
作者：
Jakeman, DL
Farrell, S
Young, W
Doucet, RJ
Timmons, SC
机构：
[1] Dalhousie Univ, Coll Pharm, Halifax, NS B3H 3J5, Canada
[2] Dalhousie Univ, Dept Chem, Halifax, NS B3H 4J3, Canada
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 05期
基金：
加拿大创新基金会;
关键词：
biosynthesis; combinatorial secondary metabolites; angucycline antibiotics; aldimine intermediates;
D O I：
10.1016/j.bmcl.2004.12.082
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural L-amino acids, D-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1447 / 1449
页数：3
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