Progress toward the development of a bacterial vaccine vector that induces high-titer long-lived broadly neutralizing antibodies against HIV-1

被引：26

作者：

Fouts, TR ^{[1
]}

DeVico, AL ^{[1
]}

Onyabe, DY ^{[1
]}

Shata, MT ^{[1
]}

Bagley, KC ^{[1
]}

Lewis, GK ^{[1
]}

Hone, DM ^{[1
]}

机构：

[1] Inst Human Virol, Div Vaccine Res, Baltimore, MD 21201 USA

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2003年 / 37卷 / 2-3期

关键词：

immunodeficiency virus; Shigella; vaccine vector; mucosal immunity; Salmonella;

D O I：

10.1016/S0928-8244(03)00067-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Conformationally constrained HIV-1 Env and gp120 immunogens induce broadly cross-reactive neutralizing antibodies. Thus, it is now feasible to rationally design an HIV-1 vaccine that affords protection through humoral mechanisms. This paper reviews our progress toward the development of an oral bacterial vaccine vector that is capable of delivering an HIV-1 DNA vaccine to host lymphoid tissues and inducing broadly neutralizing antibodies to HIV-1 in the mucosal and systemic immune compartments. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：129 / 134

页数：6

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