β-catenin Initiates Tooth Neogenesis in Adult Rodent Incisors

被引:31
作者
Liu, F. [1 ,2 ]
Dangaria, S. [3 ]
Andl, T. [1 ,2 ]
Zhang, Y. [1 ,2 ]
Wright, A. C. [4 ]
Damek-Poprawa, M. [5 ]
Piccolo, S. [6 ]
Nagy, A. [7 ]
Taketo, M. M. [8 ]
Diekwisch, T. G. H. [3 ]
Akintoye, S. O. [5 ]
Millar, S. E. [1 ,2 ]
机构
[1] Univ Penn, Sch Med, Dept Dermatol, Stellar Chance Labs M8D, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Cell & Dev Biol, Stellar Chance Labs M8D, Philadelphia, PA 19104 USA
[3] Univ Illinois, Dept Oral Biol, Coll Dent, Chicago, IL 60612 USA
[4] Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
[5] Univ Penn, Sch Dent Med, Dept Oral Med, Philadelphia, PA 19104 USA
[6] Univ Padua, Sect Histol & Embryol, Dept Histol Microbiol & Med Biotechnol, I-35121 Padua, Italy
[7] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[8] Kyoto Univ, Dept Pharmacol, Grad Sch Med, Sakyo Ku, Kyoto 6068501, Japan
关键词
tooth; development; beta-catenin; Wnt; dental; MOUSE; TRANSCRIPTION; MORPHOGENESIS; EXPRESSION; EPIDERMIS; PATHWAYS; SIGNALS; GROWTH; CELLS; AXIN2;
D O I
10.1177/0022034510370090
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
beta-catenin signaling is required for embryonic tooth morphogenesis and promotes continuous tooth development when activated in embryos. To determine whether activation of this pathway in the adult oral cavity could promote tooth development, we induced mutation of epithelial beta-catenin to a stabilized form in adult mice. This caused increased proliferation of the incisor tooth cervical loop, outpouching of incisor epithelium, abnormal morphology of the epithelial-mesenchymal junction, and enhanced expression of genes associated with embryonic tooth development. Ectopic dental-like structures were formed from the incisor region following implantation into immunodeficient mice. Thus, forced activation of beta-catenin signaling can initiate an embryonic-like program of tooth development in adult rodent incisor teeth.
引用
收藏
页码:909 / 914
页数:6
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