Investigating Neurocognitive Functioning in Youths With Externalizing Disorders From the Philadelphia Neurodevelopmental Cohort

被引：2

作者：

Honrath, Philipp ^{[1
,2
,3
]}

Kohls, Gregor ^{[4
]}

Moore, M. Tyler ^{[1
]}

Dogan, Imis ^{[2
,3
]}

Gur, C. Ruben ^{[1
]}

Habel, Ute ^{[5
,6
]}

Konrad, Kerstin ^{[3
,4
]}

Reetz, Kathrin ^{[2
,3
]}

Gur, E. Raquel ^{[1
,7
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Psychiat, Brain Behav Lab, Philadelphia, PA 19104 USA

[2] Rhein Westfal TH Aachen, Dept Neurol, Aachen, Germany

[3] Julich Aachen Res Alliance, Inst Mol Neurosci & Neuroimaging, JARA BRAIN, Aachen, Germany

[4] RWTH Aachen Univ Hosp, Child Neuropsychiat Sect, Dept Child & Adolescent Psychiat Psychosomat & Ps, Aachen, Germany

[5] RWTH Aachen Univ Hosp, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany

[6] Julich Aachen Res Alliance, JARA BRAIN, Inst Brain Struct Funct Relationships, Aachen, Germany

[7] Univ Penn, Dept Psychiat, Childrens Hosp Philadelphia CHOP, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ADOLESCENT HEALTH | 2021年 / 69卷 / 01期

关键词：

ADHD; Externalizing disorders; Disruptive behavior disorders; Neuropsychology; Sex differences; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; EXECUTIVE FUNCTION; SEX-DIFFERENCES; ADHD; ODD; SYMPTOMS; AGE; METAANALYSIS; ADOLESCENCE;

D O I：

10.1016/j.jadohealth.2020.10.029

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Purpose: Disruptive behavior disorders (DBD) and attention-deficit/hyperactivity disorder (ADHD) are externalizing disorders that frequently co-occur but also have distinct clinical characteristics. Identifying distinct neurocognitive phenotypes may help optimizing individual diagnosis and treatment of both disorders. Methods: Using data from 6,517 children and adolescents from the Philadelphia Neurodevelopmental Cohort, we investigated diagnostic group (i.e., typically developing, DBD, ADHD, DBD & thorn; ADHD) and sex differences across various neurocognitive functions, as well as co-occurring psychiatric symptoms, while adjusting for various confounding factors. Results: Neurocognitive deficits were associated with ADHD but not DBD. Co-occurring DBD in both girls and boys with ADHD did not appear to have an additive deteriorating effect on neurocognitive functioning. Task-specific sex differences were observed but did not interact with diagnostic group. Conclusions: The findings of this study suggest that neurocognitive deficits in DBD seem to be largely driven by co-occurring ADHD and this applies equally to both sexes. (c) 2020 Society for Adolescent Health and Medicine. All rights reserved.

引用

页码：100 / 107

页数：8

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