Is Myelodysplasia a Consequence of Normal Aging?

被引：8
作者：
Heibl, Sonja [1 ,2 ]
Stauder, Reinhard [3 ]
Pfeilstoecker, Michael [4 ]
机构：
[1] Klinikum Wels Grieskirchen, Dept Internal Med 4, Wels, Austria
[2] Paracelsus Med Univ, Salzburg, Austria
[3] Med Univ Innsbruck, Comprehens Canc Ctr Innsbruck CCCI, Dept Internal Med Hematol & Oncol 5, Innsbruck, Austria
[4] Hanusch Hosp, Med Dept 3, H Collinstr 30, A-1140 Vienna, Austria
来源：
CURRENT ONCOLOGY REPORTS | 2021年 / 23卷 / 12期
关键词：
Myelodysplastic syndromes; Aging; CHIP; Elderly; Clonality; Myeloid neoplasia; MURINE HEMATOPOIETIC STEM; ACUTE MYELOID-LEUKEMIA; REGULATORY T-CELLS; CLONAL HEMATOPOIESIS; PROGNOSTIC IMPACT; MUTATIONS; MDS; AGE; SURVIVAL; CANCER;
D O I：
10.1007/s11912-021-01136-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose of Review To review available data on the relationship of MDS and aging and to address the question if biological changes of (premature) aging are a prerequisite for the development of MDS. Recent Findings Whereas the association of MDS with advanced age and some common biologic features of aging and MDS are well established, additional evidence for both, especially on the role of stem cells, the stem cell niche, and inflammation, has been recently described. Biologically, many but not all drivers of aging also play a role in the development and propagation of MDS and vice versa. As a consequence, aging contributes to the development of MDS which can be seen as an interplay of clonal disease and normal and premature aging. The impact of aging may be different in specific MDS subtypes and risk groups.
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页数：11
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