Gold-Catalyzed Stereoselective Synthesis of Azacyclic Compounds through a Redox/[2+2+1] Cycloaddition Cascade of Nitroalkyne Substrates

被引：101
|
作者：
Jadhav, Appaso Mahadev [1 ]
Bhunia, Sabyasachi [1 ]
Liao, Hsin-Yi [2 ]
Liu, Rai-Shung [1 ]
机构：
[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan
[2] Natl Taipei Univ Educ, Dept Sci Educ, Taipei, Taiwan
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 06期
关键词：
GENERATION; REACTIVITY; MITOMYCIN; ALKYNES;
D O I：
10.1021/ja110514s
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a new redox/cycloaddition cascade on readily available 1-alkynyl-2-nitrobenzenes that produces complex azacyclic compounds stereoselectively. The core structures of the resulting products are constructed through a formal [2 + 2 + 1] cycloaddition among a-carbonyl carbenoids, nitroso species, and external alkenes.
引用
收藏
页码：1769 / 1771
页数：3
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