Gold-Catalyzed Stereoselective Synthesis of Azacyclic Compounds through a Redox/[2+2+1] Cycloaddition Cascade of Nitroalkyne Substrates

被引：102

作者：

Jadhav, Appaso Mahadev ^{[1
]}

Bhunia, Sabyasachi ^{[1
]}

Liao, Hsin-Yi ^{[2
]}

Liu, Rai-Shung ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan

[2] Natl Taipei Univ Educ, Dept Sci Educ, Taipei, Taiwan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 06期

关键词：

GENERATION; REACTIVITY; MITOMYCIN; ALKYNES;

D O I：

10.1021/ja110514s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a new redox/cycloaddition cascade on readily available 1-alkynyl-2-nitrobenzenes that produces complex azacyclic compounds stereoselectively. The core structures of the resulting products are constructed through a formal [2 + 2 + 1] cycloaddition among a-carbonyl carbenoids, nitroso species, and external alkenes.

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页码：1769 / 1771

页数：3

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