Immunological Evasion in Glioblastoma

被引：34
作者：
Magana-Maldonado, Roxana [1 ]
Georgina Chavez-Cortez, Elda [1 ]
Karen Olascoaga-Arellano, Nora [1 ]
Lopez-Mejia, Mariana [1 ]
Manuel Maldonado-Leal, Fernando [1 ]
Sotelo, Julio [1 ]
Pineda, Benjamin [1 ]
机构：
[1] Natl Inst Neurol & Neurosurg, Neuroimmunol & Neurooncol Unit, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
来源：
BIOMED RESEARCH INTERNATIONAL | 2016年 / 2016卷
关键词：
REGULATORY T-CELLS; MYELOID SUPPRESSOR-CELLS; BRAIN-TUMORS; GLIOMA-CELLS; PROGNOSTIC IMPACT; MESSENGER-RNA; RAT GLIOMA; EXPRESSION; MICROGLIA; STAT3;
D O I：
10.1155/2016/7487313
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Glioblastoma is the most aggressive tumor in Central Nervous System in adults. Among its features, modulation of immune system stands out. Although immune system is capable of detecting and eliminating tumor cells mainly by cytotoxic T and NK cells, tumor microenvironment suppresses an effective response through recruitment of modulator cells such as regulatory T cells, monocyte-derived suppressor cells, M2 macrophages, and microglia as well as secretion of immunomodulators including IL-6, IL-10, CSF-1, TGF-beta, and CCL2. Other mechanisms that induce immunosuppression include enzymes as indolamine 2,3-dioxygenase. For this reason it is important to develop new therapies that avoid this immune evasion to promote an effective response against glioblastoma.
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