Clinical and Cost Effectiveness of Guidelines To Prevent Intravascular Catheter-Related Infections in Patients on Hemodialysis

Sepsis is the second leading cause of death in patients with end stage renal disease (ESRD) on hemodialysis (HD). The average cost to the healthcare system for catheter-related infections (CRI) ranges from $4000 to $80,235 for each occurrence. CRI is a significant health problem leading to increased hospitalizations, morbidity, mortality, and a financial burden to the healthcare system. The purpose of this study was to evaluate the clinical and cost effectiveness of implementing published guidelines that pertain to patients on HD. Adult patients receiving long-term HD through a tunneled and cuffed HD catheter in an outpatient dialysis setting were studied. One-hundred and eighty-seven patients on HD were instituted on published guidelines (chlorhexidine to clean the exit site and HD catheters/hubs, hand washing, aseptic technique with site/dressing changes/placing patients on HD, setting up an infrastructure to support monitoring CRI) and prospectively followed from May 2009 to April 2010. Comparison was made to a retrospective cohort of 198 patients on HD from May 2008 to April 2009 in the same unit using standard care (sodium hypochlorite to clean the exit site; povidone iodine to clean the HD catheter hubs). A Hest analysis compared the two groups for differences. The number of infections decreased from 1.7 to 0.2 per 1000 catheter days during a 12-month period (p = 0.005). The number needed to prevent one adverse outcome of a CRI was 22 patients, with a relative risk of 0.11 and relative risk reduction of 89% in the treated group. The return on investment for implementing the program was 169% in one year, and the break-even point occurred within the first quarter. The projected annual savings in one dialysis unit was $141,606 using the project hospital's data and $179,010 using national data. CRI in patients on HD are preventable. The analysis revealed a significant reduction in CRI by implementing published guidelines with a significant cost savings to the healthcare system.