Elg1, a central player in genome stability

被引：14

作者：

Gazy, Inbal ^{[1
]}

Liefshitz, Batia ^{[1
]}

Parnas, Oren ^{[2
]}

Kupiec, Martin ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel

[2] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2015年 / 763卷

基金：

以色列科学基金会;

关键词：

Genome stability; DNA replication; DNA repair; Telomere length regulation; Chromatin; Sister chromatid cohesion; SISTER-CHROMATID COHESION; REPLICATION-FACTOR-C; FANCONI-ANEMIA PATHWAY; GROSS CHROMOSOMAL REARRANGEMENTS; YEAST SACCHAROMYCES-CEREVISIAE; DNA-DAMAGE CHECKPOINT; ALTERNATIVE RFC COMPLEX; STRAND BREAK REPAIR; TELOMERE LENGTH REGULATION; SUMO-INTERACTING MOTIF;

D O I：

10.1016/j.mrrev.2014.11.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

ELG1 is a conserved gene uncovered in a number of genetic screens in yeast aimed at identifying factors important in the maintenance of genome stability. Elg1's activity prevents gross chromosomal rearrangements, maintains proper telomere length regulation, helps repairing DNA damage created by a number of genotoxins and participates in sister chromatid cohesion. Elg1 is evolutionarily conserved, and its mammalian ortholog (also known as ATAD5) is embryonic lethal when lost in mice, acts as a tumor suppressor in mice and humans, exhibits physical interactions with components of the human Fanconi Anemia pathway and may be responsible for some of the phenotypes associated with neurofibromatosis. In this review, we summarize the information available on Elg1-related activities in yeast and mammals, and present models to explain how the different phenotypes observed in the absence of Elg1 activity are related. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：267 / 279

页数：13

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