BackgroundTo study the segmental uncoverage ratio (UCR) of a 44-mm cup model placed in a true acetabulum of Crowe type-IV developmental dysplasia of the hip via 3-Dimensional (3D) implantation simulation.MethodsQualified CT imaging data of 26 patients (involving 30 hips) with Crowe type-IV DDH were imported into Mimics software for reconstruction. Then a 44-mm eggshell cup model was placed in a true acetabulum. First, total uncoverage ratio (TUCR) was measured. Then the virtual cup was divided into 4 segments according to the quadrant setting of the true acetabulum, i.e., anterior-superior (A-S) segment, anterior-inferior (A-I) segment, posterior-superior (P-S) segment and posterior-inferior (P-I) segment. The UCRs of the aforementioned segments were measured, i.e., anterior-superior uncoverage ratio (A-SUCR), anterior-inferior uncoverage ratio (A-IUCR), posterior-superior uncoverage ratio (P-SUCR) and posterior-inferior uncoverage ratio (P-IUCR). The acetabular height and anterior-posterior diameter on the 3-D model were also calculated. Statistic analyses were performed by using SPSS software package.ResultsTUCR was 0.29580.1003 (95% [CI], 0.1020 to 0.5400) in this cohort of Crowe Type-IV hips. P-SUCR had the greatest value among all the segmental UCRs (0.1012 +/- 0.0435, 95% confidence interval [CI],0.0152 to 0.1914) and the most significant positive correlation with TUCR (Pearson correlation=0.889, p<0.01. Linear regression R-2=0.791). Similarly, P-IUCR and A-SUCR showed a significant positive correlation with TUCR. However, A-IUCR exhibited no correlation with either total or other segmental UCRs. P-SUCR was found to bear significant positive correlation with P-IUCR (pearson correlation=0.644, p<0.01. Linear regression R-2=0.415). Acetabular height and A-P diameter were not correlated with TUCR.Conclusion p id="Parmplantation of a 44-mm cup into Crowe type IV acetabulum is feasible and could achieve acceptable host bone coverage in most of the cases. P-SUCR contributed most to TUCR. TUCR had no linear relationship with the size of the host acetabulum, suggesting that the pre-operative plan should be individualized.