Strategies to enhance umbilical cord blood stem cell engraftment in adult patients

被引：57

作者：

Delaney, Colleen ^{[2
]}

Ratajczak, Mariusz Z. ^{[3
]}

Laughlin, Mary J. ^{[1
]}

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44106 USA

[2] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[3] James Graham Brown Canc Ctr, Stem Cell Inst, Louisville, KY 40202 USA

来源：

EXPERT REVIEW OF HEMATOLOGY | 2010年 / 3卷 / 03期

关键词：

cord blood transplantation; CXCR4; engraftment; ex vivo expansion; hematopoietic stem cell; Notch; SDF-1; stem cell homing; umbilical cord blood; HEMATOPOIETIC STEM/PROGENITOR CELLS; COMPLEMENT COMPONENT C3; EX-VIVO EXPANSION; COPPER CHELATOR TETRAETHYLENEPENTAMINE; MOBILIZED PERIPHERAL-BLOOD; HOMING-RELATED RESPONSES; NOTCH LIGAND DELTA1; LONG-TERM CULTURES; BONE-MARROW; SELF-RENEWAL;

D O I：

10.1586/EHM.10.24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Umbilical cord blood (UCB) has been used successfully as a source of hematopoietic stem cells (HSCs) for allogeneic transplantation in children and adults in the treatment of hematologic diseases. However, compared with marrow or mobilized peripheral blood stem cell grafts from adult donors, significant delays in the rates and kinetics of neutrophil and platelet engraftment are noted after UCB transplant. These differences relate in part to the reduced numbers of HSCs in UCB grafts. To improve the rates and kinetics of engraftment of UCB HSC, several strategies have been proposed, including ex vivo expansion of UCB HSCs, addition of third-party mesenchymal cells, intrabone delivery of HSCs, modulation of CD26 expression, and infusion of two UCB grafts. This article will focus on ex vivo expansion of UCB HSCs and strategies to enhance UCB homing as potential solutions to overcome the problem of low stem cell numbers in a UCB graft.

引用

页码：273 / 283

页数：11

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