Antibacterial and bactericidal activity of nitric oxide-releasing natural zeolite

被引：34

作者：

Narin, Guler ^{[1
]}

Albayrak, Cisem Bulut ^{[1
]}

Ulku, Semra ^{[1
]}

机构：

[1] Izmir Inst Technol, Dept Chem Engn, TR-35430 Izmir, Turkey

来源：

APPLIED CLAY SCIENCE | 2010年 / 50卷 / 04期

关键词：

Clinoptilolite rich natural zeolite; Nitric oxide adsorption; Antibacterial activity; Bactericidal activity; Nitric oxide release kinetics; DELIVERY-SYSTEM; DRUG SUPPORT; CLINOPTILOLITE; NO; ADSORPTION; KINETICS; EXCHANGE; ANGIOGENESIS; MECHANISMS; REACTIVITY;

D O I：

10.1016/j.clay.2010.10.013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The zeolitic tuff from Gordes (Western Anatolia) was used as adsorbent for nitric oxide (NO) storage and release purposes The NO loading of the zeolite was performed under 20 mL min(-1) NO flow at 30 C and then the zeolite was purged with inert gas in order to remove the species that were reversibly adsorbed and in the gas phase (desorption) The total and reversible adsorption capacities of the zeolite were determined from the adsorption and desorption breakthrough curves respectively The NO-loaded zeolite exhibited antibacterial and bactericidal activities against Gram-negative (Escherichia colt) and Gram positive bacteria (Bacillus subtilis) under physiological conditions From the NO release kinetics the diffusion coefficient of NO in the zeolite particle was determined (C) 2010 Elsevier B V All rights reserved

引用

页码：560 / 568

页数：9

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